Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 3 914 160 0.0382 0.0434 0.1751 0.1958
A-375 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 3 8546 338 0.3934 0.4342 0.0396 0.0408
A-375 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 3 962 146 0.0413 0.0433 0.1518 0.1382
A-375 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 3 947 180 0.0388 0.0433 0.1901 0.1874
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 22342 1082 1.0188 1.0000 0.0484 0.0468
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 18747 969 0.8520 0.8197 0.0517 0.0506
A-375 Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 3 4259 158 0.2077 0.1953 0.0371 0.0349
A-375 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 3 5915 430 0.2777 0.2714 0.0727 0.0654
A-375 Vemurafenib Dasatinib 1.000 1.000
uM
 72
hr
 3 717 65 0.0330 0.0398 0.0907 0.1218
A-375 Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 3 2902 98 0.1420 0.1658 0.0338 0.0359
A-375 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 3 1130 64 0.0540 0.0577 0.0566 0.0487
A-375 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 3 1153 176 0.0495 0.0492 0.1526 0.1635
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 3 21481 1121 1.0310 1.0000 0.0522 0.0504
A-375 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 3 8666 164 0.4305 0.4180 0.0189 0.0173
A-375 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 3 5737 112 0.2848 0.2652 0.0195 0.0225
A-375 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 3 1204 56 0.0581 0.0636 0.0465 0.0545
A-375 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 3 3533 99 0.1739 0.1709 0.0280 0.0246
A-375 Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 3 3339 171 0.1604 0.1539 0.0512 0.0544
A-375 Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 3 1056 45 0.0512 0.0545 0.0426 0.0467
A-375 Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 3 2383 59 0.1177 0.1200 0.0248 0.0313
A-375 Vemurafenib Dasatinib 1.000 3.160
uM
 72
hr
 3 1023 106 0.0464 0.0490 0.1036 0.0884
A-375 Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 3 3598 270 0.1685 0.1621 0.0750 0.0672
A-375 Vemurafenib Dasatinib 0.100 3.160
uM
 72
hr
 3 1677 72 0.0813 0.0917 0.0429 0.0407
A-375 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 3 7654 162 0.3590 0.4565 0.0212 0.0200
A-375 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 2006 239 0.0847 0.0889 0.1191 0.1262
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