Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 3 7109 392 2.1297 1.5833 0.0551 0.0617
MZ7-mel Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 6287 334 1.9416 1.4168 0.0531 0.0618
MZ7-mel Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 2 5203 279 1.5612 1.5833 0.0536 0.0617
MZ7-mel Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 3 5704 336 1.5486 1.3927 0.0589 0.0616
MZ7-mel Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 2 5640 348 1.5267 1.3927 0.0617 0.0616
MZ7-mel Vemurafenib Saracatinib 0.000 3.160
uM
 72
hr
 1 4872 354 1.4736 0.9734 0.0727 0.0805
MZ7-mel Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 2 4806 288 1.4736 1.4168 0.0599 0.0618
MMAC-SF Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 2 1516 54 1.4357 1.3028 0.0356 0.0415
MMAC-SF Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 1846 89 1.4019 1.3011 0.0482 0.0459
MMAC-SF Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 3 1476 60 1.3905 1.3028 0.0407 0.0415
MMAC-SF Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 3 1432 72 1.3770 1.2926 0.0503 0.0509
MMAC-SF Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 2 1771 79 1.3500 1.3011 0.0446 0.0459
MZ7-mel Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 4472 217 1.3491 0.9268 0.0485 0.0478
MMAC-SF Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 2 1398 83 1.3314 1.2926 0.0594 0.0509
MZ7-mel Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 6060 359 1.2527 1.1499 0.0592 0.0651
MMAC-SF Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 2119 106 1.2403 1.1047 0.0500 0.0462
MZ7-mel Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 2 6042 428 1.2336 1.1499 0.0708 0.0651
MMAC-SF Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 3 1676 108 1.2009 1.0853 0.0644 0.0619
MMAC-SF Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 2 2014 89 1.1861 1.1047 0.0442 0.0462
MMAC-SF Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 1 1207 52 1.1694 1.2926 0.0431 0.0509
A-375 Vemurafenib (+)-JQ1 0.000 0.000
uM
 72
hr
 1 17083 736 1.1561 1.0000 0.0431 0.0814
MMAC-SF Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 2 1603 97 1.1534 1.0853 0.0605 0.0619
MMAC-SF Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 1 1511 68 1.1513 1.3011 0.0450 0.0459
MMAC-SF Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 1504 69 1.1449 1.0000 0.0459 0.0496
A-375 Vemurafenib I-BET151 0.000 0.000
uM
 72
hr
 1 17149 1786 1.1105 1.0000 0.1041 0.1052
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