Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 2 2562 425 0.3053 0.3034 0.1659 0.1673
COLO 858 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 3 2637 462 0.3107 0.3034 0.1752 0.1673
COLO 858 Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 1 1252 898 0.0506 0.0508 0.7173 0.7144
COLO 858 Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 2 1208 870 0.0483 0.0508 0.7202 0.7144
COLO 858 Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 3 1275 900 0.0536 0.0508 0.7059 0.7144
COLO 858 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 1 1374 845 0.0756 0.0722 0.6150 0.5817
COLO 858 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 2 1227 686 0.0773 0.0722 0.5591 0.5817
COLO 858 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 3 1042 595 0.0639 0.0722 0.5710 0.5817
COLO 858 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 1 1347 812 0.0764 0.0748 0.6028 0.5989
COLO 858 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 2 1274 753 0.0744 0.0748 0.5911 0.5989
COLO 858 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 3 1297 782 0.0736 0.0748 0.6029 0.5989
COLO 858 Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 1 1706 704 0.1431 0.1375 0.4127 0.4603
COLO 858 Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 2 1621 824 0.1139 0.1375 0.5083 0.4603
COLO 858 Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 3 2014 926 0.1554 0.1375 0.4598 0.4603
COLO 858 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 1 840 724 0.0166 0.0153 0.8619 0.8976
COLO 858 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 2 1187 1073 0.0163 0.0153 0.9040 0.8976
COLO 858 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 3 1258 1166 0.0131 0.0153 0.9269 0.8976
COLO 858 Vemurafenib Dasatinib 1.000 1.000
uM
 72
hr
 1 1426 1207 0.0313 0.0266 0.8464 0.8544
COLO 858 Vemurafenib Dasatinib 1.000 1.000
uM
 72
hr
 2 1286 1097 0.0270 0.0266 0.8530 0.8544
COLO 858 Vemurafenib Dasatinib 1.000 1.000
uM
 72
hr
 3 1108 957 0.0216 0.0266 0.8637 0.8544
COLO 858 Vemurafenib Dasatinib 1.000 3.160
uM
 72
hr
 1 1198 988 0.0300 0.0300 0.8247 0.8251
COLO 858 Vemurafenib Dasatinib 1.000 3.160
uM
 72
hr
 2 1120 918 0.0289 0.0300 0.8196 0.8251
COLO 858 Vemurafenib Dasatinib 1.000 3.160
uM
 72
hr
 3 1290 1072 0.0311 0.0300 0.8310 0.8251
COLO 858 Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 1 1509 1201 0.0440 0.0314 0.7959 0.8595
COLO 858 Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 2 1560 1386 0.0249 0.0314 0.8885 0.8595