Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 3 1681 1503 0.0254 0.0314 0.8941 0.8595
COLO 858 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 1 1135 1078 0.0081 0.0064 0.9498 0.9579
COLO 858 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 2 937 901 0.0051 0.0064 0.9616 0.9579
COLO 858 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 3 1090 1049 0.0059 0.0064 0.9624 0.9579
COLO 858 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 1 1440 1382 0.0083 0.0084 0.9597 0.9531
COLO 858 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 2 1275 1218 0.0081 0.0084 0.9553 0.9531
COLO 858 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 3 1093 1032 0.0087 0.0084 0.9442 0.9531
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 1 1247 1183 0.0091 0.0097 0.9487 0.9430
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 2 1231 1160 0.0101 0.0097 0.9423 0.9430
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 3 1115 1046 0.0099 0.0097 0.9381 0.9430
COLO 858 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 1 10128 1461 1.0290 1.0000 0.1443 0.1501
COLO 858 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 2 10083 1500 1.0190 1.0000 0.1488 0.1501
COLO 858 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 9513 1495 0.9520 1.0000 0.1572 0.1501
COLO 858 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 8772 1469 0.8671 0.8985 0.1675 0.1651
COLO 858 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 2 8670 1397 0.8635 0.8985 0.1611 0.1651
COLO 858 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 9755 1627 0.9650 0.8985 0.1668 0.1651
COLO 858 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 1 4700 704 0.4744 0.5301 0.1498 0.1528
COLO 858 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 2 5704 880 0.5727 0.5301 0.1543 0.1528
COLO 858 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 3 5409 834 0.5432 0.5301 0.1542 0.1528
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 1 1609 714 0.1063 0.1023 0.4438 0.4297
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 2 1666 709 0.1136 0.1023 0.4256 0.4297
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 1265 531 0.0871 0.1023 0.4198 0.4297
COLO 858 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 1 4152 336 0.4531 0.4516 0.0809 0.0851
COLO 858 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 2 4062 356 0.4400 0.4516 0.0876 0.0851
COLO 858 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 3 4258 369 0.4617 0.4516 0.0867 0.0851