Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | GSK461364 | PLK1 | PLK | 9095.001 | uM | 0.17731 | 2.57920 | -0.9719 | -1.0000 | 0.4103 | 0.4637 | 0.7474 | 1.0444 | |
| 184B5 | NM | Basal | GSK923295 | CENPE | Kinesin | 9095.001 | uM | 1.82040 | 10.84810 | -0.6893 | -1.0000 | 0.6155 | 0.3102 | 0.7760 | 1.0444 | |
| 184B5 | NM | Basal | GW-5074 | CRAF | MAPK | 5897.088 | uM | 2.70550 | 3.11820 | -0.1725 | -0.1816 | 2.1826 | 0.2410 | 0.9894 | 1.2950 | |
| 184B5 | NM | Basal | Ibandronate | FDPS | 12566.143 | uM | 246.04810 | 377.53870 | -0.8325 | -0.8991 | 2.4033 | 0.2099 | 0.9974 | 1.6413 | ||
| 184B5 | NM | Basal | ICRF-193 | TOP2 | TOP | 12566.171 | uM | inf | 0.13728 | 0.6403 | 0.6293 | 1.2114 | 0.1786 | 0.9288 | 1.5151 | |
| 184B5 | NM | Basal | IKK16 | IKK | NFKB | 5897.093 | uM | 1.73350 | 2.93910 | -0.9487 | -0.9879 | 2.0655 | 0.4622 | 0.9967 | 1.2047 | |
| 184B5 | NM | Basal | Imatinib | ABL/KIT/PDGFR | nRTK | 5896.091 | uM | 23.18150 | 34.00000 | -0.9493 | -0.9584 | 2.7948 | 0.4637 | 0.9940 | 1.4988 | |
| 184B5 | NM | Basal | Imatinib | ABL/KIT/PDGFR | nRTK | 5897.091 | uM | 24.73780 | 35.23660 | -0.9547 | -0.9568 | 3.0230 | 0.4186 | 0.9990 | 1.2296 | |
| 184B5 | NM | Basal | Ispinesib | KSP | Kinesin | 5896.067 | uM | 0.56462 | 3.31620 | -0.9349 | -1.0000 | 0.6205 | 0.4400 | 0.9084 | 1.4536 | |
| 184B5 | NM | Basal | Ispinesib | KSP | Kinesin | 5897.067 | uM | 1.94680 | 2.77930 | -0.9633 | -0.9674 | 3.0241 | 0.4080 | 0.9827 | 1.1908 | |
| 184B5 | NM | Basal | Ixabepilone | TUBB | TUBB | 5896.095 | uM | 0.08255 | 0.56666 | -0.9288 | -1.0000 | 0.5703 | 0.7131 | 0.9537 | 1.5532 | |
| 184B5 | NM | Basal | Ixabepilone | TUBB | TUBB | 5897.095 | uM | 0.20628 | 0.87310 | -0.9665 | -1.0000 | 0.7614 | 0.6402 | 0.9623 | 1.2197 | |
| 184B5 | NM | Basal | JNK-IN-5A | JNK | JNK | 12566.168 | uM | 197.47390 | 224.21850 | 0.4789 | -0.4434 | 4.9982 | 0.0157 | 0.9558 | 1.4366 | |
| 184B5 | NM | Basal | L-779450 | BRAF | MAPK | 12566.166 | uM | 3.60120 | 8.28470 | -0.5360 | -0.8326 | 1.1766 | 0.2021 | 0.9933 | 1.2010 | |
| 184B5 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 5896.098 | uM | 19.73470 | 1.01420 | 0.5024 | 0.4466 | 0.7535 | 0.1314 | 0.9743 | 1.6038 | |
| 184B5 | NM | Basal | LBH589 | HDAC | HDAC | 12566.167 | uM | 0.13317 | 0.57457 | -0.4488 | -0.6154 | 0.5488 | 0.5171 | 0.9826 | 1.5941 | |
| 184B5 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12566.167 | uM | 0.40063 | 1.20680 | -0.8855 | -1.0000 | 0.9963 | 0.5481 | 0.9929 | 1.5941 | |
| 184B5 | NM | Basal | Mebendazole | 12979.174 | uM | inf | 0.50538 | 0.5338 | 0.6450 | 4.9853 | 0.1589 | 0.6593 | 1.5680 | |||
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 5896.084 | uM | 0.02683 | 0.03281 | -0.4711 | -0.4849 | 3.3686 | 1.0619 | 0.9980 | 1.5200 | |
| 184B5 | NM | Basal | Methotrexate | DHFR | Metabolism | 5897.085 | uM | 0.04372 | 0.05133 | -0.6179 | -0.6153 | 5.0000 | 1.1076 | 0.9993 | 1.2392 | |
| 184B5 | NM | Basal | MG-132 | Proteasome | Proteasome | 12566.17 | uM | 0.01702 | 0.03186 | -0.6444 | -0.5157 | 1.1297 | 0.9111 | 0.9667 | 1.4648 | |
| 184B5 | NM | Basal | MG-132 | Proteasome | Proteasome | 12566.17 | uM | 0.01702 | 0.03186 | -0.6444 | -0.5157 | 1.1297 | 0.9111 | 0.9667 | 1.4648 | |
| 184B5 | NM | Basal | Pevonedistat | NAE1 | NAE1 | 12566.135 | uM | 0.15715 | 0.62079 | -0.4838 | -0.5023 | 0.5062 | 0.5445 | 0.9747 | 1.6384 | |
| 184B5 | NM | Basal | Nelfinavir | 12979.174 | uM | 5.2970 | 7.9410 | -0.7445 | -0.8032 | 2.3659 | 0.1847 | 0.9934 | 1.5680 | |||
| 184B5 | NM | Basal | Nilotinib | ABL | nRTK | 12566.17 | uM | inf | 0.08710 | 0.9223 | 0.9254 | 0.8046 | 0.0464 | 0.8541 | 1.4648 |