Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
184B5	NM	Basal	NSC 663284	CDC25	CDC	12566.152	uM	2.37290	3.20490	-0.8860	-0.8796	3.3767	0.5784	0.9988	1.4827
184B5	NM	Basal	NU6102	CDK1/2	CDK	12566.147	uM	4.55970	10.7450	-0.8630	-1.0000	1.2816	0.2945	0.9979	1.6169
184B5	NM	Basal	Nutlin 3a	MDM2	MDM2	5896.066	uM	2.29050	11.45910	-0.9381	-1.0000	0.6824	0.3705	0.8514	1.4224
184B5	NM	Basal	Nutlin 3a	MDM2	MDM2	5897.066	uM	13.78730	20.17590	-0.9537	-1.0000	2.8854	0.1920	0.9917	1.2737
184B5	NM	Basal	Olomoucine II	CDK1	CDK	12566.147	uM	3.35670	5.86570	-0.3694	-0.4572	1.1635	0.3493	0.9899	1.6169
184B5	NM	Basal	Omipalisib	PI3K	PI3K	5897.086	uM	0.00620	0.01729	-0.6593	-0.4574	0.6340	0.8271	0.9483	1.2814
184B5	NM	Basal	Oxaliplatin	DNA cross-linker	DNA cross-linker	9095.119	uM	3.22860	15.96270	-0.9485	-1.0000	0.6874	0.6144	0.9570	1.2263
184B5	NM	Basal	Oxamflatin	HDAC	HDAC	12566.147	uM	1.13190	3.48360	-0.8575	-1.0000	0.9773	0.5020	0.9814	1.6169
184B5	NM	Basal	PD 98059	MEK	MAPK	12566.152	uM	inf	inf	0.9069	0.9069	0.0000	0.0066	0.4227	1.4827
184B5	NM	Basal	PD173074	FGFR1/3	RTK	5897.093	uM	28.42620	33.05570	0.2039	-0.5632	4.9999	0.0088	0.9753	1.2047
184B5	NM	Basal	PD184352	MEK	MAPK	12566.155	uM	3.29320	33.01680	-0.0750	-1.0000	0.4766	0.2503	0.9170	1.5389
184B5	NM	Basal	PD184352	MEK	MAPK	12566.155	uM	3.29320	33.01680	-0.0750	-1.0000	0.4766	0.2503	0.9170	1.5389
184B5	NM	Basal	Pemetrexed	TYMS/DHFR/GARFT	TYMS	5896.095	uM	0.24202	0.32119	-0.2838	-0.2743	1.5454	0.9106	0.9931	1.5532
184B5	NM	Basal	Pemetrexed	TYMS/DHFR/GARFT	TYMS	5897.095	uM	0.52125	0.66097	-0.3237	-0.3105	2.0341	0.8593	0.9969	1.2197
184B5	NM	Basal	PS-1145	IKK	NFKB	5896.065	uM	inf	inf	0.9046	0.9046	0.0000	0.0309	0.3134	1.4978
184B5	NM	Basal	PS-1145	IKK	NFKB	5897.065	uM	inf	inf	0.9561	0.9561	0.0000	0.0500	0.3340	1.2996
184B5	NM	Basal	Purvalanol A	CDK1	CDK	5896.067	uM	2.11650	1.66090	0.2353	0.3509	4.9920	0.2073	0.9594	1.4536
184B5	NM	Basal	Purvalanol A	CDK1	CDK	5897.067	uM	12.87360	13.92180	-0.3686	-0.2376	4.9663	0.2133	0.9779	1.1908
184B5	NM	Basal	QNZ	NFkB	NFKB	5897.096	uM	0.03394	0.04191	-0.9427	-0.9339	4.9999	1.0267	0.9995	1.2810
184B5	NM	Basal	SB-3CT	MMP2/9	MMP	12566.168	uM	inf	7.14330	0.8537	0.8575	4.9996	0.0287	0.8045	1.4366
184B5	NM	Basal	Selumetinib	MEK	MAPK	12566.155	uM	0.14380	0.11679	0.0605	0.0667	0.6885	0.4452	0.9875	1.5389
184B5	NM	Basal	Sigma A6730	AKT	AKT	12566.165	uM	2.97380	8.22950	-0.8497	-1.0000	1.0793	0.4028	0.9697	1.7248
184B5	NM	Basal	Sirolimus	MTOR	MTOR	7789.068	uM	inf	inf	-0.9304	-0.9304	0.0000	1.0723	0.4470	0.3219
184B5	NM	Basal	Sirolimus	MTOR	MTOR	5896.069	uM	inf	0.00571	0.7756	0.7626	1.4422	0.1582	0.9050	1.5507
184B5	NM	Basal	Sorafenib	PDGFR/VEGFR/KIT/FLT3	RTK	5896.084	uM	5.08750	9.01390	-0.8428	-0.5815	1.3488	0.5354	0.9603	1.5200

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)