Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 7793.018 | uM | 245.40250 | 372.22010 | -0.9147 | -0.9315 | 2.5250 | 0.5517 | 0.9016 | 1.3186 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9146.122 | uM | inf | 0.50973 | 0.5528 | 0.5712 | 1.2270 | 0.1353 | 0.9205 | 1.3408 | ||
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9146.049 | uM | inf | inf | 0.5485 | 0.5485 | 0.0000 | 0.3293 | 0.0796 | 1.1054 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7794.017 | uM | 3.22820 | 6.31960 | -0.8625 | -0.8951 | 1.5276 | 0.5428 | 0.9934 | 1.9851 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7793.035 | uM | 1.31960 | 2.70440 | -0.9763 | -0.9664 | 1.4995 | 0.6864 | 0.9942 | 1.2119 | |
| AU565 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9035.017 | uM | 2.2380 | 6.31910 | -0.9109 | -0.9976 | 1.0569 | 0.5825 | 0.9942 | 2.2905 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 7793.007 | uM | 0.97073 | 1.86150 | -0.6733 | -0.6755 | 1.3129 | 0.4892 | 0.9947 | 1.3832 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 9035.077 | uM | 4.62530 | 5.80490 | -0.1848 | -0.1990 | 1.4748 | 0.2389 | 0.9957 | 2.3909 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 9146.121 | uM | 1.40740 | 2.19440 | -0.6284 | -0.6026 | 1.7804 | 0.4336 | 0.9975 | 1.1366 | |
| AU565 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 10880.155 | uM | 0.27813 | 0.23011 | 0.5266 | 0.3062 | 5.0000 | 0.3052 | 0.6953 | 1.5205 | |
| AU565 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 13030.176 | uM | inf | inf | 0.8188 | 0.8188 | 0.0000 | 0.0150 | 0.5497 | 0.9892 | |
| AU565 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 13030.174 | uM | 0.17478 | 0.16713 | 0.3533 | 0.1003 | 5.0000 | 0.4165 | 0.8114 | 0.8615 | |
| AU565 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 13030.002 | uM | 0.00092 | 0.00128 | -0.9104 | -0.8772 | 3.0709 | 1.3116 | 0.9975 | 0.5732 | |
| AU565 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9146.002 | uM | 0.00498 | 0.00636 | -0.6733 | -0.6767 | 3.4844 | 0.9399 | 0.9984 | 1.2611 | |
| AU565 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 7793.002 | uM | 0.00459 | 0.00690 | -0.8647 | -0.8640 | 2.4584 | 1.0405 | 0.9993 | 1.1545 | |
| AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9146.121 | uM | 0.10032 | 0.22291 | -0.9894 | -0.9912 | 1.3687 | 0.9716 | 0.9813 | 1.1366 | |
| AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 7793.007 | uM | 0.09387 | 0.22089 | -0.9529 | -0.9559 | 1.2490 | 0.9331 | 0.9887 | 1.3832 | |
| AU565 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9035.077 | uM | 0.10927 | 0.29945 | -0.9043 | -0.8852 | 1.0108 | 0.8193 | 0.9916 | 2.3909 | |
| AU565 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 9035.017 | uM | 0.15993 | 0.19598 | -0.8793 | -0.2970 | 2.2943 | 0.7775 | 0.5906 | 2.2905 | |
| AU565 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7794.017 | uM | 0.13634 | 0.36050 | -0.9484 | -0.8758 | 1.0409 | 0.8678 | 0.9898 | 1.9851 | |
| AU565 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7793.035 | uM | 0.12215 | 0.18964 | -0.9918 | -0.9217 | 2.3757 | 1.0184 | 0.9961 | 1.2119 | |
| AU565 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 5900.092 | uM | 22.11190 | 37.99340 | 0.1765 | -0.8772 | 1.8718 | 0.0574 | 0.9942 | 2.6334 | |
| AU565 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 5901.091 | uM | 8.69220 | 14.69410 | -0.3289 | -0.5059 | 1.3314 | 0.1854 | 0.9974 | 1.9229 | |
| AU565 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 5900.074 | uM | 0.98749 | 1.56220 | -0.5584 | -0.4906 | 1.4905 | 0.6041 | 0.9955 | 2.4189 | |
| AU565 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 5901.074 | uM | 0.51180 | 1.05610 | -0.7095 | -0.6601 | 1.1618 | 0.7400 | 0.9963 | 1.8718 |