Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7794.017 | uM | 3.63770 | 2.00040 | 0.0921 | 0.3519 | 2.0349 | 0.4369 | 0.8863 | 1.9851 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7793.035 | uM | 7.14650 | 49.68870 | -0.3950 | -0.5513 | 0.3832 | 0.7305 | 0.9781 | 1.2119 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9035.017 | uM | 234.20810 | 255.89090 | 0.0352 | -0.0320 | 0.6997 | 0.3489 | 0.9930 | 2.2905 | |
| AU565 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 5901.066 | uM | inf | 7.61680 | 0.8636 | 0.8635 | 4.6384 | 0.0208 | 0.8425 | 1.9445 | |
| AU565 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 5900.066 | uM | inf | 6.12470 | 0.8829 | 0.8829 | 4.9899 | 0.0099 | 0.8759 | 2.7232 | |
| AU565 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7793.016 | uM | 3.46870 | 2.11450 | 0.2602 | 0.4579 | 5.0000 | 0.1890 | 0.6309 | 1.1616 | |
| AU565 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7794.016 | uM | 6.34340 | 7.11680 | -0.4152 | -0.3888 | 4.9996 | 0.3500 | 0.9976 | 1.9541 | |
| AU565 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 10880.153 | uM | 19.34270 | 462.49130 | 0.3870 | -1.0000 | 0.3461 | 0.1624 | 0.9033 | 1.6896 | |
| AU565 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 10880.072 | uM | 54.59420 | 140.52680 | -0.1140 | -1.0000 | 1.1620 | 0.1307 | 0.9721 | 1.6177 | |
| AU565 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 5900.072 | uM | 49.7210 | 95.25030 | -0.2566 | -0.8052 | 1.4759 | 0.1407 | 0.9904 | 2.5162 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 5900.074 | uM | 0.02550 | 0.03474 | -0.7420 | -0.7576 | 2.9828 | 1.1668 | 0.9988 | 2.4189 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 5900.074 | uM | 0.02550 | 0.03474 | -0.7420 | -0.7576 | 2.9828 | 1.1668 | 0.9988 | 2.4189 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 14817.203 | uM | 0.00278 | 0.00465 | -0.8411 | -0.8434 | 1.9229 | 1.3693 | 0.9990 | 1.5445 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 14817.203 | uM | 0.00278 | 0.00465 | -0.8411 | -0.8434 | 1.9229 | 1.3693 | 0.9990 | 1.5445 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 5901.074 | uM | 0.01918 | 0.02631 | -0.9339 | -0.9340 | 3.3341 | 1.3219 | 0.9993 | 1.8718 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 5901.074 | uM | 0.01918 | 0.02631 | -0.9339 | -0.9340 | 3.3341 | 1.3219 | 0.9993 | 1.8718 | |
| AU565 | HER2amp | Luminal | Bosutinib | Src | nRTK | 10880.145 | uM | 3.02630 | 5.850 | -0.9379 | -1.0000 | 1.6668 | 0.5000 | 0.9733 | 1.4751 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9146.12 | uM | 8.75290 | 22.23960 | -0.9696 | -1.0000 | 1.1781 | 0.6456 | 0.9948 | 1.1135 | |
| AU565 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7793.011 | uM | 13.66430 | 31.58610 | -0.9791 | -1.0000 | 1.3111 | 0.5984 | 0.9959 | 1.1456 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9146.122 | uM | inf | inf | 0.9694 | 0.9694 | 0.0000 | -0.0404 | -1.9847 | 1.3408 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7793.018 | uM | inf | inf | 0.9318 | 0.9318 | 0.0000 | 0.0067 | 0.3477 | 1.3186 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9035.018 | uM | inf | inf | 0.9083 | 0.9083 | 0.0000 | 0.0297 | 0.4162 | 2.1555 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7794.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.6812 | |
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9035.018 | uM | 536.59930 | 1000.00000 | 0.1872 | -0.0935 | 0.2755 | 0.2729 | 0.8107 | 2.1555 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 7794.018 | uM | 903.45840 | 1000.00000 | -0.5938 | -0.3307 | 5.0000 | 0.0895 | 0.8461 | 1.6812 |