Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
184B5	NM	Basal	CPT-11	TOP1	TOP	9095.121	uM	2.51920	28.77490	-0.2643	-0.9655	0.4415	0.3101	0.9565	1.1992
184B5	NM	Basal	Dactolisib	PI3K	PI3K	12566.155	uM	0.10180	0.09596	0.1073	0.1279	4.9998	0.4116	0.9754	1.5389
184B5	NM	Basal	Dichloroacetate	PDK	PDK	12979.176	uM	inf	0.01220	0.9086	0.8652	4.8576	0.0350	0.7045	1.0091
184B5	NM	Basal	Disulfiram	Proteasome	Proteasome	12979.174	uM	13.46160	19.5890	-0.9600	-1.0000	2.9286	0.2119	0.9801	1.5680
184B5	NM	Basal	Docetaxel	TUBB	TUBB	12979.002	uM	inf	inf	0.7220	0.7220	0.0000	0.1667	0.1607	1.3178
184B5	NM	Basal	Docetaxel	TUBB	TUBB	9095.002	uM	0.00444	0.00218	0.4170	0.3901	2.1393	0.3930	0.9566	1.0607
184B5	NM	Basal	Doxorubicin	TOP2	TOP	9095.121	uM	0.11890	0.22542	-0.9889	-0.9914	1.7083	0.9694	0.9884	1.1992
184B5	NM	Basal	Erlotinib	EGFR	ErbB	5896.091	uM	0.19497	0.13149	0.0999	0.1474	0.8866	0.4253	0.9753	1.4988
184B5	NM	Basal	Erlotinib	EGFR	ErbB	5897.091	uM	1.28840	1.31750	0.0348	-0.0092	0.8129	0.3029	0.9812	1.2296
184B5	NM	Basal	Etoposide	TOP2	TOP	5896.074	uM	4.08810	48.86320	-0.4513	-1.0000	0.4428	0.4398	0.9738	1.4124
184B5	NM	Basal	Etoposide	TOP2	TOP	5897.074	uM	20.40170	44.09240	-0.1173	-0.3858	0.7421	0.2819	0.9802	1.2824
184B5	NM	Basal	Everolimus	MTOR	MTOR	12566.164	uM	3.63690	995.7980	0.2684	-0.8205	0.1730	0.3513	0.8480	1.5173
184B5	NM	Basal	Fascaplysin	CDK4	CDK	5897.085	uM	0.32680	0.48798	-0.9650	-0.9672	2.6852	0.6599	0.9981	1.2392
184B5	NM	Basal	Fascaplysin	CDK4	CDK	5896.084	uM	0.23326	0.34203	-0.9161	-0.9115	2.7115	0.6772	0.9996	1.5200
184B5	NM	Basal	FR180204	ERK1/2	MAPK	12566.166	uM	12.86090	9.57870	0.2046	0.1774	1.4873	0.1461	0.9905	1.2010
184B5	NM	Basal	FTase Inhibitor I	Ftase	MAPK	12566.167	uM	inf	12.16790	0.9467	0.9467	4.9807	0.0009	0.7447	1.5941
184B5	NM	Basal	Gefitinib	EGFR	ErbB	9095.049	uM	0.03643	0.04877	-0.2658	-0.1449	0.8727	0.5606	0.9843	1.1202
184B5	NM	Basal	Geldanamycin	HSP90	HSP90	9095.049	uM	0.00859	0.01158	-0.7576	-0.7255	2.9985	1.2019	0.9991	1.1202
184B5	NM	Basal	Gemcitabine	DNA replication	DNA replication	9095.119	uM	0.39268	1000.00000	-0.4244	-0.9804	0.1384	0.6890	0.7465	1.2263
184B5	NM	Basal	Glycyl-H-1152	ROCK2		12566.169	uM	211.26010	999.92730	0.5910	-0.3569	0.3465	0.1053	0.8971	1.6359
184B5	NM	Basal	GM6001	MMP	MMP	5897.096	uM	inf	inf	0.9590	0.9590	0.0000	0.0206	-0.0228	1.2810
184B5	NM	Basal	GSK1070916	AURK	AURK	9095.001	uM	0.66025	4.63870	-0.5752	-1.0000	0.5635	0.3925	0.9830	1.0444
184B5	NM	Basal	GSK1838705A	IGF1R	RTK	5896.091	uM	0.48701	0.70366	-0.3389	-0.2060	0.9377	0.4902	0.9631	1.4988
184B5	NM	Basal	GSK1838705A	IGF1R	RTK	5897.091	uM	2.5180	9.36910	-0.9343	-1.0000	0.8361	0.4350	0.9858	1.2296
184B5	NM	Basal	GSK1838705A	IGF1R	RTK	5896.098	uM	0.53928	1.50110	-0.3784	-0.4487	0.6256	0.4433	0.9874	1.6038

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)