Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 5910.098 | uM | 8.24970 | 12.33540 | -0.8174 | -0.8459 | 2.4613 | 0.2304 | 0.9978 | 3.2046 | |
| BT-549 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 5909.098 | uM | 6.56190 | 8.060 | -0.8961 | -0.8980 | 5.0000 | 0.3085 | 0.9980 | 2.6253 | |
| BT-549 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 5909.092 | uM | 5.07990 | 6.30740 | -0.7169 | -0.7170 | 4.1102 | 0.3216 | 0.9990 | 3.0314 | |
| BT-549 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 10261.001 | uM | 0.06157 | 0.15170 | -0.4222 | -0.4109 | 0.6651 | 0.5699 | 0.9713 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 10261.001 | uM | 0.05714 | 0.05080 | 0.2077 | 0.2224 | 4.9999 | 0.3810 | 0.9940 | 2.3472 | |
| BT-549 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 5909.088 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0255 | -2.9579 | 2.9659 | |
| BT-549 | TNBC | Basal B | Ibandronate | FDPS | 12305.143 | uM | 53.37830 | 83.05540 | -0.1213 | -0.2169 | 0.8149 | 0.2814 | 0.9980 | 2.9115 | ||
| BT-549 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 12305.157 | uM | inf | 0.22786 | 0.6315 | 0.5881 | 0.3501 | 0.1796 | 0.8666 | 2.9955 | |
| BT-549 | TNBC | Basal B | IKK16 | IKK | NFKB | 5909.093 | uM | 3.93910 | 5.24310 | -0.7387 | -0.7395 | 3.1748 | 0.3229 | 0.9982 | 2.8805 | |
| BT-549 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 5910.091 | uM | 30.89130 | 37.75620 | -0.7258 | -0.7260 | 4.4692 | 0.3217 | 0.9982 | 3.3208 | |
| BT-549 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 5909.092 | uM | 36.52830 | 49.83120 | -0.7507 | -0.7525 | 2.9569 | 0.3310 | 0.9990 | 3.0314 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 5909.067 | uM | 0.48057 | 4.71140 | -0.8153 | -1.0000 | 0.4813 | 0.3869 | 0.8366 | 2.8695 | |
| BT-549 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 5910.067 | uM | 0.38893 | 4.22180 | -0.8117 | -1.0000 | 0.4607 | 0.4056 | 0.8370 | 3.2630 | |
| BT-549 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 5910.095 | uM | 0.00666 | 0.02630 | -0.8108 | -0.5522 | 0.5415 | 0.8403 | 0.9352 | 3.2727 | |
| BT-549 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 5909.095 | uM | 0.02139 | 0.25211 | -0.8830 | -1.0000 | 0.4454 | 0.7826 | 0.9588 | 2.7716 | |
| BT-549 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 12305.168 | uM | 0.91330 | 1.02980 | -0.1585 | -0.1267 | 1.8821 | 0.4405 | 0.9868 | 2.5025 | |
| BT-549 | TNBC | Basal B | L-779450 | BRAF | MAPK | 12305.166 | uM | 50.02890 | 43.34140 | 0.8426 | 0.2560 | 4.9997 | 0.0132 | 0.6646 | 2.9556 | |
| BT-549 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 5910.098 | uM | inf | inf | 0.9455 | 0.9455 | 0.0000 | -0.0163 | 0.2428 | 3.2046 | |
| BT-549 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 5909.098 | uM | inf | 6.25710 | 0.8768 | 0.8207 | 0.8467 | 0.0108 | 0.6521 | 2.6253 | |
| BT-549 | TNBC | Basal B | LBH589 | HDAC | HDAC | 12305.167 | uM | 0.19318 | 0.45314 | -0.5767 | -0.6104 | 0.9358 | 0.5337 | 0.9989 | 2.8814 | |
| BT-549 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12305.167 | uM | 1.61670 | 6.36660 | -0.7128 | -1.0000 | 0.8015 | 0.3323 | 0.9667 | 2.8814 | |
| BT-549 | TNBC | Basal B | Mebendazole | 12690.174 | uM | 0.52406 | 0.39147 | 0.2665 | 0.2879 | 2.9394 | 0.2959 | 0.9947 | 2.4378 | |||
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 5909.085 | uM | inf | inf | 0.9298 | 0.9298 | 0.0000 | -0.0072 | 0.3654 | 3.0853 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 5910.084 | uM | inf | inf | 0.9374 | 0.9374 | 0.0000 | -0.0121 | 0.4733 | 3.1096 | |
| BT-549 | TNBC | Basal B | Methylglyoxal | 13153.184 | uM | 173.18360 | 482.92460 | -0.9268 | -0.9819 | 1.0594 | 0.7769 | 0.9329 | 2.3850 |