Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Ro 32-0432 | PKC | PKC | 10473.142 | uM | inf | inf | 1.0380 | 1.0380 | 0.0000 | -0.0178 | -0.2214 | 1.0815 | |
| CAMA-1 | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 12070.144 | uM | inf | inf | 0.8317 | 0.8317 | 0.0000 | 0.0762 | 0.1224 | 1.1742 | |
| CAMA-1 | HR+ | Luminal | Selumetinib | MEK | MAPK | 10755.146 | uM | inf | inf | 0.7223 | 0.7223 | 0.0000 | 0.1526 | 0.4825 | 0.8035 | |
| CAMA-1 | HR+ | Luminal | Selumetinib | MEK | MAPK | 12070.155 | uM | inf | 0.19248 | 0.8618 | 0.8946 | 1.6293 | 0.0419 | 0.7660 | 1.1729 | |
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10473.141 | uM | 5.97870 | 15.75880 | -0.6868 | -1.0000 | 1.1335 | 0.3294 | 0.9551 | 1.2804 | |
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10755.153 | uM | 10.12190 | 11.78250 | -0.5684 | -0.5687 | 5.0000 | 0.2778 | 0.9603 | 0.7471 | |
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 12070.158 | uM | 2.60090 | 7.86290 | -0.8870 | -1.0000 | 0.9931 | 0.3840 | 0.9790 | 1.1252 | |
| CAMA-1 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7805.068 | uM | 0.00849 | 0.00815 | -0.2105 | 0.0163 | 0.8149 | 0.7353 | 0.9263 | 0.8633 | |
| CAMA-1 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 5911.068 | uM | 0.01408 | 0.01156 | 0.0336 | 0.1058 | 1.2029 | 0.6546 | 0.9810 | 0.9873 | |
| CAMA-1 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 5912.069 | uM | 0.03669 | 0.03299 | -0.0122 | 0.0322 | 0.6262 | 0.5126 | 0.9818 | 0.9582 | |
| CAMA-1 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5912.084 | uM | 766.13020 | 1000.00000 | 0.4668 | -0.0794 | 0.5535 | 0.1352 | 0.8112 | 1.0966 | |
| CAMA-1 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5911.084 | uM | 20.33960 | 33.53810 | -0.7616 | -0.7737 | 1.8697 | 0.4881 | 0.9961 | 1.0262 | |
| CAMA-1 | HR+ | Luminal | Sulindac sulfide | COX1/2 | COX | 10473.136 | uM | inf | inf | 0.9598 | 0.9598 | 0.0000 | 0.0241 | 0.0000 | 1.3186 | |
| CAMA-1 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5912.067 | uM | 8.33920 | 10.91890 | -0.9743 | -0.9761 | 4.0165 | 0.4450 | 0.9947 | 1.1725 | |
| CAMA-1 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5911.067 | uM | 7.6070 | 9.77620 | -0.9909 | -0.9918 | 4.3572 | 0.4414 | 0.9968 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Taxol | TUBB | TUBB | 9210.002 | uM | 0.01086 | 0.01202 | -0.3518 | -0.3303 | 4.9965 | 0.8093 | 0.9977 | 0.8958 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 10473.14 | uM | 1.05240 | 1.88470 | -0.6353 | -0.6914 | 1.4900 | 0.4421 | 0.9807 | 1.3126 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 10755.152 | uM | 0.66362 | 1.51340 | -0.9273 | -0.9919 | 1.3261 | 0.5276 | 0.9879 | 0.5859 | |
| CAMA-1 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 12070.159 | uM | 0.54336 | 0.97998 | -0.9595 | -0.9754 | 1.8348 | 0.5187 | 0.9981 | 0.9846 | |
| CAMA-1 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12070.135 | uM | inf | inf | 0.7536 | 0.7536 | 0.0000 | 0.1198 | 0.1619 | 1.2457 | |
| CAMA-1 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10473.135 | uM | inf | inf | 0.5662 | 0.5662 | 0.0000 | 0.0922 | 0.3589 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10755.148 | uM | inf | inf | 0.5279 | 0.5279 | 0.0000 | 0.2240 | 0.4039 | 0.6379 | |
| CAMA-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 12070.144 | uM | 0.04893 | 1.40230 | -0.9418 | -1.0000 | 0.3274 | 0.7534 | 0.9098 | 1.1742 | |
| CAMA-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 9210.121 | uM | 0.39996 | 5.10 | -0.6908 | -1.0000 | 0.4316 | 0.5442 | 0.9511 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Torkinib | 15348.211 | uM | 0.00176 | 0.01477 | -0.8919 | -0.9141 | 0.4883 | 1.1876 | 0.9886 | 0.7490 |