Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | TAPI-0 | TACE/Collagenase | 7430.096 | uM | inf | 999.99990 | 0.7702 | 0.3543 | 0.1950 | 0.0991 | 0.6784 | 2.0162 | ||
| HCC1143 | TNBC | Basal A | Taxol | TUBB | TUBB | 9233.002 | uM | 0.020 | 0.02774 | -0.4917 | -0.4178 | 1.8553 | 0.7713 | 0.9932 | 0.9358 | |
| HCC1143 | TNBC | Basal A | Taxol | TUBB | TUBB | 7810.002 | uM | 0.01074 | 0.01641 | -0.4474 | -0.4159 | 1.4293 | 0.8227 | 0.9941 | 1.1625 | |
| HCC1143 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 12112.159 | uM | 0.31472 | 0.40098 | -0.3586 | -0.3324 | 2.1041 | 0.4622 | 0.9941 | 1.8609 | |
| HCC1143 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 12112.135 | uM | inf | inf | 0.7748 | 0.7748 | 0.0000 | 0.0840 | 0.3883 | 1.8185 | |
| HCC1143 | TNBC | Basal A | Temsirolimus | MTOR | MTOR | 12112.144 | uM | 3.08980 | 23.90030 | -0.8230 | -1.0000 | 0.5370 | 0.4266 | 0.8180 | 1.9163 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 9233.121 | uM | 0.16811 | 1.07840 | -0.6689 | -0.7583 | 0.4965 | 0.6340 | 0.9803 | 0.9468 | |
| HCC1143 | TNBC | Basal A | Topotecan | TOP1 | TOP | 7810.007 | uM | 0.26583 | 1.0380 | -0.7669 | -0.7962 | 0.6993 | 0.6310 | 0.9903 | 0.9616 | |
| HCC1143 | TNBC | Basal A | Torkinib | 15349.211 | uM | 0.00212 | 0.02884 | -0.5325 | -0.6450 | 0.3174 | 0.9231 | 0.9841 | 1.2538 | |||
| HCC1143 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12112.16 | uM | 1.5480 | 34.97250 | -0.0267 | -1.0000 | 0.3524 | 0.2951 | 0.9667 | 1.7073 | |
| HCC1143 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 7430.093 | uM | 10.07660 | 4.31640 | 0.4563 | 0.4520 | 2.7641 | 0.1304 | 0.9765 | 1.9432 | |
| HCC1143 | TNBC | Basal A | Trametinib | MEK | MAPK | 7810.012 | uM | inf | 0.00809 | 0.5737 | 0.5441 | 2.0492 | 0.2622 | 0.9610 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Trastuzumab | HER2 | ErbB | 9233.124 | uM | inf | inf | 0.8121 | 0.8121 | 0.0000 | 0.0617 | 0.3873 | 0.9990 | |
| HCC1143 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 7430.065 | uM | 16.73570 | 21.96270 | -0.5867 | -0.4256 | 2.2657 | 0.5930 | 0.9879 | 1.9263 | |
| HCC1143 | TNBC | Basal A | Triciribine | AKT | AKT | 7430.074 | uM | 3.52560 | 68.90220 | 0.1321 | -0.9991 | 0.3694 | 0.2363 | 0.9801 | 1.6943 | |
| HCC1143 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 12112.143 | uM | 987.2540 | 1000.00000 | -0.2576 | -0.0082 | 1.2700 | 0.1793 | 0.8673 | 1.6893 | |
| HCC1143 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7810.006 | uM | 0.23157 | 0.26143 | -0.7939 | -0.1519 | 2.1883 | 0.6704 | 0.7555 | 0.9730 | |
| HCC1143 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7809.018 | uM | 0.02987 | 0.02334 | 0.2866 | 0.3546 | 5.0000 | 0.3657 | 0.9630 | 1.6742 | |
| HCC1143 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 7430.065 | uM | 143.29490 | 208.10230 | -0.3499 | -0.3272 | 1.3491 | 0.4600 | 0.9965 | 1.9263 | |
| HCC1143 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 12112.157 | uM | 11.75790 | 0.56131 | 0.5118 | 0.4877 | 1.2188 | 0.2507 | 0.7951 | 2.0505 | |
| HCC1143 | TNBC | Basal A | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14203.189 | uM | 0.53646 | 0.96874 | -0.8428 | -0.8522 | 1.6834 | 0.6454 | 0.9944 | 1.6955 | |
| HCC1143 | TNBC | Basal A | ZM-447439 | AURK | AURK | 12112.16 | uM | 2.1830 | 0.50095 | 0.4358 | 0.4738 | 2.0026 | 0.2316 | 0.9687 | 1.7073 | |
| HCC1187 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7812.016 | uM | inf | inf | 0.8355 | 0.8355 | 0.0000 | 0.0454 | 0.3718 | 1.0628 | ||
| HCC1187 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7811.044 | uM | 11.65150 | 16.05880 | -1.0000 | -0.9995 | 3.4233 | 0.3459 | 0.9975 | 0.3073 | ||
| HCC1187 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7811.04 | uM | 1.04690 | 1.38930 | -1.0000 | -0.9258 | 3.7023 | 0.7792 | 0.8482 | 0.3921 |