Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9158.002 | uM | 0.00864 | 0.01271 | -0.8158 | -0.7150 | 2.3051 | 1.0217 | 0.9943 | 0.4298 | |
| BT-474 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9163.002 | uM | 0.00813 | 0.01227 | -0.7896 | -0.7362 | 2.1969 | 1.0501 | 0.9969 | 0.6004 | |
| BT-474 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 12291.152 | uM | 0.33462 | 0.95937 | -0.5600 | -0.7174 | 0.8448 | 0.5273 | 0.9614 | 0.6792 | |
| BT-474 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 12056.159 | uM | 0.55373 | 1.08780 | -0.5378 | -0.5858 | 1.1485 | 0.4584 | 0.9896 | 0.9145 | |
| BT-474 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 12178.159 | uM | 1.25010 | 1.70650 | -0.4681 | -0.4697 | 2.1283 | 0.3306 | 0.9939 | 0.6130 | |
| BT-474 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12291.135 | uM | inf | inf | 0.5594 | 0.5594 | 0.0000 | 0.2732 | -0.0096 | 0.4536 | |
| BT-474 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12178.135 | uM | inf | inf | 0.9217 | 0.9217 | 0.0000 | -0.0119 | 0.2808 | 0.5524 | |
| BT-474 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12056.135 | uM | inf | inf | 0.7081 | 0.7081 | 0.0000 | 0.1158 | 0.4107 | 0.9361 | |
| BT-474 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 12056.144 | uM | 0.04627 | 3.88920 | -0.9770 | -1.0000 | 0.2479 | 0.6966 | 0.7390 | 0.9738 | |
| BT-474 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 12178.144 | uM | 0.00674 | 4.77920 | -0.5971 | -1.0000 | 0.1674 | 0.7546 | 0.7765 | 0.7891 | |
| BT-474 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 12291.168 | uM | -inf | 0.00735 | -0.9999 | -1.0000 | 0.2001 | 1.2788 | 0.8809 | 0.4466 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 9163.121 | uM | 0.71948 | 2.42440 | -0.7636 | -0.8550 | 0.8207 | 0.5390 | 0.9879 | 0.4382 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 7798.077 | uM | 31.4570 | 8.71650 | 0.3936 | 0.3174 | 0.7847 | 0.1331 | 0.9887 | 1.4371 | |
| BT-474 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 9158.121 | uM | 2.47970 | 4.70910 | -0.5275 | -0.5447 | 1.1489 | 0.3894 | 0.9893 | 1.0691 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12178.16 | uM | inf | inf | 0.2658 | 0.2658 | 0.0000 | 0.1429 | 0.5449 | 0.7392 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12056.16 | uM | 21.99290 | 50.19930 | 0.2578 | -1.0000 | 1.3312 | 0.1084 | 0.7948 | 0.9124 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12291.169 | uM | 6.18190 | 14.50510 | -0.9859 | -1.0000 | 1.2881 | 0.3744 | 0.9158 | 0.3548 | |
| BT-474 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 5905.093 | uM | inf | inf | 0.8892 | 0.8892 | 0.0000 | -0.0060 | 0.0525 | 0.9101 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9157.012 | uM | inf | inf | 0.7933 | 0.7933 | 0.0000 | 0.0840 | 0.4934 | 0.8641 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9163.024 | uM | 44.54640 | 122.93040 | 0.7877 | -0.9791 | 1.0684 | 0.0080 | 0.7001 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9158.123 | uM | 0.01277 | 0.00885 | -0.0100 | 0.0993 | 0.6043 | 0.4533 | 0.9046 | 0.8769 | |
| BT-474 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9163.026 | uM | 0.00135 | 0.0020 | -0.6688 | -0.4240 | 1.5559 | 0.8993 | 0.9648 | 0.3738 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5906.065 | uM | 7.71060 | 10.80850 | -0.9938 | -0.9980 | 3.2489 | 0.9661 | 0.9945 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5905.065 | uM | 10.69090 | 15.04820 | -0.9632 | -0.9609 | 3.1364 | 0.8807 | 0.9976 | 0.8461 | |
| BT-474 | HER2amp | Luminal | Triciribine | AKT | AKT | 5906.074 | uM | 0.01550 | 0.02634 | -0.2986 | -0.2004 | 0.6357 | 0.6325 | 0.9018 | 0.6442 |