Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Triciribine | AKT | AKT | 5905.074 | uM | 0.07957 | 0.15194 | -0.2667 | -0.3062 | 0.7386 | 0.5707 | 0.9369 | 0.8648 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 12178.143 | uM | 463.94180 | 1000.00000 | -0.9713 | -0.7580 | 1.2014 | 0.4048 | 0.9150 | 0.7617 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 12056.143 | uM | 391.07680 | 1000.00000 | -0.9342 | -0.7776 | 0.9992 | 0.3918 | 0.9185 | 1.0075 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 12291.143 | uM | 717.16620 | 1000.00000 | -0.9964 | -0.7984 | 2.8704 | 0.3234 | 0.9803 | 0.5621 | |
| BT-474 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7798.018 | uM | 0.07033 | 1.33570 | -0.8933 | -1.0000 | 0.3732 | 0.6131 | 0.8869 | 1.4461 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 5906.065 | uM | 39.50840 | 80.74350 | -0.9927 | -1.0000 | 1.5370 | 0.8548 | 0.9977 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 5905.065 | uM | 65.67480 | 118.77110 | -0.9633 | -0.9775 | 1.8287 | 0.7654 | 0.9989 | 0.8461 | |
| BT-474 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 12056.157 | uM | inf | 0.25218 | 0.6336 | 0.6521 | 1.1164 | 0.2064 | 0.5892 | 0.9748 | |
| BT-474 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 12291.157 | uM | 1.31810 | 1.41760 | -0.2813 | -0.2196 | 4.9996 | 0.4789 | 0.9519 | 0.5161 | |
| BT-474 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 12178.157 | uM | 3.83080 | 5.02370 | -0.3595 | -0.2713 | 1.5988 | 0.3017 | 0.9796 | 0.5528 | |
| BT-474 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14233.189 | uM | 0.23986 | 0.55671 | -0.9876 | -0.9894 | 1.2963 | 0.7600 | 0.9937 | 0.3780 | |
| BT-474 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14119.189 | uM | 1.43850 | 2.09160 | -0.5407 | -0.5210 | 1.9072 | 0.4272 | 0.9968 | 1.2143 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12178.16 | uM | inf | inf | 0.5577 | 0.5577 | 0.0000 | 0.3142 | 0.4077 | 0.7392 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12291.169 | uM | 2.74420 | 2.49370 | -0.0499 | 0.1902 | 5.0000 | 0.2447 | 0.7269 | 0.3548 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12056.16 | uM | 18.20560 | 49.54740 | -0.4446 | -1.0000 | 1.0973 | 0.3126 | 0.7841 | 0.9124 | |
| BT-483 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7801.016 | uM | 22.32320 | 38.86550 | -0.9618 | -1.0000 | 1.9813 | 0.3751 | 0.8751 | 0.4118 | ||
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7801.037 | uM | 0.10644 | 0.52164 | -0.9762 | -0.9265 | 0.6596 | 0.7616 | 0.9437 | 0.3490 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9186.037 | uM | 0.14337 | 1.08130 | -0.9871 | -1.0000 | 0.5437 | 0.6949 | 0.9553 | 0.5199 | |
| BT-483 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 11855.143 | uM | 22.20910 | 916.2230 | -0.3934 | -1.0000 | 0.2954 | 0.5025 | 0.9381 | 0.5372 | |
| BT-483 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10696.143 | uM | 63.52740 | 851.88480 | -0.3979 | -1.0000 | 0.4232 | 0.4208 | 0.9738 | 0.5188 | |
| BT-483 | HR+ | Luminal | 5-FU | TYMS | TYMS | 7801.035 | uM | 29.55510 | 200.52440 | -0.8268 | -0.9602 | 0.5598 | 0.7045 | 0.9953 | 0.5427 | |
| BT-483 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 11855.158 | uM | 0.79652 | 3.89470 | -0.9969 | -1.0000 | 0.6922 | 0.6114 | 0.8444 | 0.6941 | |
| BT-483 | HR+ | Luminal | AG1024 | IGF1R | RTK | 5908.066 | uM | inf | inf | 0.0534 | 0.0534 | 0.0000 | 0.3542 | 0.4565 | 0.4546 | |
| BT-483 | HR+ | Luminal | AG1478 | EGFR | ErbB | 7801.016 | uM | inf | inf | 0.6635 | 0.6635 | 0.0000 | 0.1429 | 0.360 | 0.4118 | |
| BT-483 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 11855.158 | uM | 189.98210 | 0.08709 | 0.5149 | 0.4464 | 0.2904 | 0.2863 | 0.7511 | 0.6941 |