Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 12003.145 | uM | 0.56081 | 0.87303 | -0.6361 | -0.6280 | 1.8382 | 0.5574 | 0.9948 | 0.9611 | |
| ZR-75-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 11660.145 | uM | 0.47233 | 1.21540 | -0.8693 | -0.8719 | 1.0678 | 0.5829 | 0.9976 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 11660.145 | uM | 0.47233 | 1.21540 | -0.8693 | -0.8719 | 1.0678 | 0.5829 | 0.9976 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 11660.148 | uM | inf | 0.28689 | 0.5250 | 0.5073 | 0.9287 | 0.2499 | 0.7230 | 1.1480 | |
| ZR-75-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 12003.135 | uM | 0.78281 | 0.50730 | 0.1934 | 0.0727 | 0.3619 | 0.3755 | 0.9268 | 0.9898 | |
| ZR-75-1 | HR+ | Luminal | Nelfinavir | 12677.174 | uM | 10.14370 | 15.38150 | -0.7713 | -1.0000 | 2.6389 | 0.1589 | 0.9889 | 0.9992 | |||
| ZR-75-1 | HR+ | Luminal | Nilotinib | ABL | nRTK | 12003.145 | uM | inf | inf | 0.9728 | 0.9728 | 0.0000 | 0.0104 | 0.0000 | 0.9611 | |
| ZR-75-1 | HR+ | Luminal | Nilotinib | ABL | nRTK | 11660.145 | uM | inf | 8.21380 | 0.6802 | 0.7742 | 4.9993 | 0.0697 | 0.7382 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 12003.159 | uM | 1.3180 | 2.03380 | -0.9596 | -0.9811 | 2.5036 | 0.8286 | 0.9208 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 11660.152 | uM | 2.14610 | 3.81460 | -0.9796 | -0.9934 | 1.9024 | 0.6309 | 0.9941 | 0.9953 | |
| ZR-75-1 | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 12003.147 | uM | 6.9470 | 21.39630 | -0.5767 | -1.0000 | 0.9766 | 0.3650 | 0.8273 | 1.1884 | |
| ZR-75-1 | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 11660.147 | uM | 20.51450 | 57.39670 | -0.0971 | -1.0000 | 1.0678 | 0.2060 | 0.8857 | 1.0592 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 7552.066 | uM | 3.24430 | 16.45390 | -0.4580 | -1.0000 | 0.6766 | 0.3325 | 0.9736 | 1.0180 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 7553.066 | uM | 2.71910 | 7.20920 | -0.5483 | -0.7351 | 0.9275 | 0.3585 | 0.9753 | 0.9707 | |
| ZR-75-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 10444.066 | uM | 1.71310 | 6.75260 | -0.5954 | -0.8801 | 0.7402 | 0.3941 | 0.9806 | 0.9196 | |
| ZR-75-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 12003.147 | uM | 6.41970 | 6.39740 | -0.1672 | 0.0086 | 5.0000 | 0.3163 | 0.8655 | 1.1884 | |
| ZR-75-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 11660.147 | uM | 7.57160 | 8.21220 | -0.3544 | -0.2505 | 5.0000 | 0.3486 | 0.9277 | 1.0592 | |
| ZR-75-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 7553.086 | uM | 0.00624 | 0.01999 | -0.7384 | -0.6927 | 0.7464 | 0.9756 | 0.9947 | 1.0750 | |
| ZR-75-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 10444.087 | uM | 0.01064 | 0.02450 | -0.8393 | -0.7724 | 1.1205 | 0.9750 | 0.9969 | 0.8325 | |
| ZR-75-1 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9958.021 | uM | 2.61520 | 8.32030 | -0.9996 | -1.0000 | 0.9493 | 0.6504 | 0.9645 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7932.011 | uM | 2.31640 | 9.37920 | -0.9746 | -1.0000 | 0.7856 | 0.6687 | 0.9845 | 0.9025 | |
| ZR-75-1 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7931.011 | uM | 2.85350 | 15.48740 | -0.9222 | -1.0000 | 0.6495 | 0.6106 | 0.9887 | 1.2993 | |
| ZR-75-1 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 12003.147 | uM | 1.75560 | 8.28140 | -0.8786 | -1.0000 | 0.7082 | 0.4604 | 0.8990 | 1.1884 | |
| ZR-75-1 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 11660.147 | uM | 2.21290 | 6.05560 | -0.9635 | -1.0000 | 1.0913 | 0.4442 | 0.9788 | 1.0592 | |
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 11660.152 | uM | inf | inf | 0.6556 | 0.6556 | 0.0000 | 0.1306 | 0.1757 | 0.9953 |