Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 10754.145 | uM | 0.19949 | 0.32540 | -0.7442 | -0.7200 | 1.8230 | 0.7278 | 0.9978 | 1.0421 | |
| UACC-812 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 10754.145 | uM | 0.19949 | 0.32540 | -0.7442 | -0.7200 | 1.8230 | 0.7278 | 0.9978 | 1.0421 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 11938.135 | uM | 0.43443 | 0.93430 | -0.4532 | -0.3719 | 0.7261 | 0.5616 | 0.7857 | 0.6853 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 10580.135 | uM | 1.37730 | 39.98740 | -0.0056 | -1.0000 | 0.3262 | 0.3907 | 0.8671 | 0.9868 | |
| UACC-812 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 10754.148 | uM | 0.91495 | 1.43080 | -0.3197 | -0.3373 | 1.1531 | 0.4191 | 0.9834 | 1.1406 | |
| UACC-812 | HER2amp | Luminal | Nelfinavir | 13078.174 | uM | inf | inf | 0.9914 | 0.9914 | 0.0000 | 0.0487 | 0.0000 | 0.6238 | |||
| UACC-812 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 11938.145 | uM | inf | inf | 0.8147 | 0.8147 | 0.0000 | 0.2353 | 0.1910 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 10754.145 | uM | inf | inf | 0.7392 | 0.7392 | 0.0000 | 0.1574 | 0.2761 | 1.0421 | |
| UACC-812 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 10580.145 | uM | 623.34810 | 1000.00000 | 0.4580 | -0.0483 | 0.1950 | 0.2060 | 0.6657 | 0.9000 | |
| UACC-812 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 10580.14 | uM | 2.2040 | 4.42210 | -0.9917 | -1.0000 | 1.5777 | 0.6243 | 0.9914 | 0.8679 | |
| UACC-812 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 10754.152 | uM | 2.29330 | 4.88850 | -0.9666 | -1.0000 | 1.4515 | 0.5876 | 0.9931 | 1.0670 | |
| UACC-812 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 11938.159 | uM | 3.85130 | 4.79760 | -0.9999 | -0.9999 | 5.0000 | 0.5553 | 0.9983 | 0.4219 | |
| UACC-812 | HER2amp | Luminal | NU6102 | CDK1/2 | CDK | 11938.147 | uM | 19.62890 | 24.45250 | -0.9901 | -1.0000 | 4.9998 | 0.3913 | 0.7152 | 0.6765 | |
| UACC-812 | HER2amp | Luminal | NU6102 | CDK1/2 | CDK | 10754.147 | uM | 51.38670 | 65.24170 | 0.2430 | -0.4690 | 2.7716 | 0.1187 | 0.7310 | 1.2793 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 7547.066 | uM | 0.96205 | 51.03620 | -0.2045 | -1.0000 | 0.2766 | 0.4207 | 0.7421 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 10420.066 | uM | 3.67120 | 9.62410 | -0.6668 | -0.8822 | 1.0550 | 0.2844 | 0.9932 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | Olomoucine II | CDK1 | CDK | 11938.147 | uM | 5.620 | 7.54930 | -0.9969 | -1.0000 | 3.7226 | 0.5772 | 0.9236 | 0.6765 | |
| UACC-812 | HER2amp | Luminal | Olomoucine II | CDK1 | CDK | 10754.147 | uM | 7.50240 | 7.28980 | 0.0013 | 0.0669 | 5.0000 | 0.2143 | 0.9803 | 1.2793 | |
| UACC-812 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 7547.087 | uM | 0.00057 | 0.00410 | -0.5482 | -0.6130 | 0.4045 | 1.0863 | 0.9374 | 0.9847 | |
| UACC-812 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10420.087 | uM | 0.00156 | 0.00805 | -0.8526 | -0.8583 | 0.6089 | 1.2060 | 0.9671 | 0.5834 | |
| UACC-812 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10580.087 | uM | 0.00444 | 0.01384 | -0.6778 | -0.6645 | 0.7435 | 1.0224 | 0.9856 | 0.8285 | |
| UACC-812 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10754.087 | uM | 0.01241 | 0.02099 | -0.2824 | -0.2603 | 0.7976 | 0.7186 | 0.9880 | 1.2170 | |
| UACC-812 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10150.021 | uM | 2.16490 | 4.71260 | -0.9996 | -0.9075 | 1.3305 | 0.7126 | 0.9610 | 0.4883 | |
| UACC-812 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10267.011 | uM | 0.62062 | 3.3460 | -0.9989 | -1.0000 | 0.6521 | 0.7991 | 0.9714 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10151.021 | uM | 0.21571 | 0.96877 | -1.0000 | -1.0000 | 0.7314 | 1.0052 | 0.9765 | 0.3048 |