Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 12003.159 | uM | inf | inf | 0.4060 | 0.4060 | 0.0000 | 0.2531 | 0.490 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 10444.093 | uM | 10.05660 | 19.1860 | -0.4476 | -1.0000 | 1.7008 | 0.2437 | 0.8956 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 7553.093 | uM | 15.65140 | 35.63880 | 0.0366 | -1.0000 | 1.3351 | 0.1487 | 0.9188 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 11660.146 | uM | 583.9090 | 1000.00000 | 0.4704 | -0.0361 | 0.1295 | 0.2471 | 0.6207 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 11660.146 | uM | 583.9090 | 1000.00000 | 0.4704 | -0.0361 | 0.1295 | 0.2471 | 0.6207 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 12003.155 | uM | inf | 0.00501 | 0.8304 | 0.8464 | 0.5638 | 0.1047 | 0.6326 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 12003.155 | uM | inf | 0.00501 | 0.8304 | 0.8464 | 0.5638 | 0.1047 | 0.6326 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7552.095 | uM | 283.16160 | 264.75520 | 0.1397 | 0.1427 | 5.0000 | 0.2204 | 0.9126 | 1.1106 | |
| ZR-75-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7553.095 | uM | 0.22608 | 0.08707 | 0.3980 | 0.4452 | 2.3166 | 0.4525 | 0.9707 | 1.1473 | |
| ZR-75-1 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7553.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0337 | -2.7068 | 1.0305 | |
| ZR-75-1 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7552.065 | uM | inf | inf | 0.9528 | 0.9528 | 0.0000 | 0.0308 | 0.1104 | 1.1323 | |
| ZR-75-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7553.067 | uM | inf | 198.88240 | 0.8686 | 0.5659 | 4.7905 | -0.0009 | 0.6110 | 1.1302 | |
| ZR-75-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7552.067 | uM | 29.95480 | 15.47670 | 0.4611 | 0.4816 | 5.0000 | 0.1146 | 0.9648 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | QNZ | NFkB | NFKB | 7553.096 | uM | 0.05947 | 0.02437 | 0.2664 | 0.3269 | 1.1891 | 0.3945 | 0.9421 | 1.1407 | |
| ZR-75-1 | HR+ | Luminal | Ribavirin | 15346.211 | uM | inf | inf | 0.7643 | 0.7643 | 0.0000 | 0.0402 | -0.0208 | 0.6395 | |||
| ZR-75-1 | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 12003.168 | uM | inf | inf | 0.7827 | 0.7827 | 0.0000 | 0.1268 | -0.0117 | 1.1370 | |
| ZR-75-1 | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 11660.144 | uM | 119.48650 | 98.97520 | 0.5398 | 0.0841 | 0.9775 | 0.0781 | 0.8604 | 1.0279 | |
| ZR-75-1 | HR+ | Luminal | Selumetinib | MEK | MAPK | 12003.155 | uM | inf | inf | 0.7852 | 0.7852 | 0.0000 | 0.1164 | 0.5363 | 1.1249 | |
| ZR-75-1 | HR+ | Luminal | Selumetinib | MEK | MAPK | 11660.146 | uM | 5.02770 | 999.65480 | 0.2909 | -0.7800 | 0.1776 | 0.3153 | 0.9108 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 11660.153 | uM | 1.41070 | 17.97910 | -0.2748 | -1.0000 | 0.4317 | 0.4000 | 0.9343 | 0.8197 | |
| ZR-75-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 12003.165 | uM | 0.26905 | 1.07040 | -0.7554 | -0.7752 | 0.6780 | 0.5948 | 0.9734 | 1.0267 | |
| ZR-75-1 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7552.084 | uM | 19.66180 | 64.79560 | -0.8315 | -0.9096 | 0.8691 | 0.4079 | 0.9641 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7553.085 | uM | 68.44260 | 82.31120 | -0.7562 | -0.7579 | 5.0000 | 0.1326 | 0.9958 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7552.067 | uM | 10.03460 | 12.54540 | -0.9796 | -0.9797 | 4.8587 | 0.3735 | 0.9983 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7553.067 | uM | 11.63830 | 14.79810 | -0.9723 | -0.9723 | 4.4963 | 0.3638 | 0.9990 | 1.1302 |