Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 12003.157 | uM | 3.97190 | 2.18140 | 0.4190 | 0.0603 | 0.2146 | 0.3302 | 0.7495 | 1.0729 | |
| ZR-75-1 | HR+ | Luminal | IKK16 | IKK | NFKB | 10444.093 | uM | 3.91630 | 5.28390 | -0.9686 | -0.9700 | 3.6002 | 0.4495 | 0.9865 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | IKK16 | IKK | NFKB | 7553.093 | uM | 4.13320 | 5.78270 | -0.9589 | -0.9605 | 3.1920 | 0.4169 | 0.9936 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7553.091 | uM | 25.84550 | 36.14520 | -0.9869 | -0.9890 | 3.2535 | 0.4001 | 0.9979 | 0.9738 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7552.067 | uM | 0.09778 | 1.39620 | -0.9808 | -1.0000 | 0.4132 | 0.5343 | 0.8126 | 1.0224 | |
| ZR-75-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7553.067 | uM | 0.09440 | 1.36560 | -0.9722 | -1.0000 | 0.4112 | 0.5429 | 0.8298 | 1.1302 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7553.095 | uM | 0.08527 | 2.84440 | -0.9700 | -1.0000 | 0.3132 | 0.5455 | 0.6946 | 1.1473 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7552.095 | uM | 0.45694 | 0.82765 | -0.9734 | -0.9844 | 1.8318 | 0.6203 | 0.9968 | 1.1106 | |
| ZR-75-1 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 12003.168 | uM | 6.51220 | 2.50280 | 0.4806 | 0.4958 | 5.0000 | 0.2143 | 0.8277 | 1.1370 | |
| ZR-75-1 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 11660.144 | uM | 0.54362 | 0.43447 | 0.2310 | 0.3370 | 4.9998 | 0.2977 | 0.9227 | 1.0279 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 12003.166 | uM | inf | inf | 0.3485 | 0.3485 | 0.0000 | 0.2159 | 0.5536 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 11660.149 | uM | inf | inf | 0.3716 | 0.3716 | 0.0000 | 0.1545 | 0.5721 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7552.098 | uM | inf | inf | 0.8246 | 0.8246 | 0.0000 | 0.1123 | 0.2173 | 1.1882 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7553.098 | uM | inf | inf | 0.8279 | 0.8279 | 0.0000 | 0.1327 | 0.2591 | 1.2325 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 12003.167 | uM | 0.06810 | 0.20743 | -0.2023 | -0.3669 | 0.4941 | 0.5643 | 0.9694 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 11660.154 | uM | 0.28287 | 0.47918 | -0.7804 | -0.7918 | 1.8008 | 0.6537 | 0.9845 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12003.167 | uM | 1.41090 | 10.49420 | -0.3709 | -1.0000 | 0.5475 | 0.3641 | 0.9076 | 1.1158 | |
| ZR-75-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11660.154 | uM | 1.28590 | 10.59590 | -0.3306 | -1.0000 | 0.5209 | 0.3588 | 0.9488 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | Mebendazole | 12677.174 | uM | 0.22970 | 0.26999 | -0.4152 | -0.1899 | 1.9923 | 0.5178 | 0.9488 | 0.9992 | |||
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7552.084 | uM | 0.02302 | 0.01642 | 0.3234 | 0.3625 | 3.8221 | 0.4995 | 0.9792 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7553.085 | uM | 0.15669 | 0.02563 | 0.4402 | 0.4717 | 1.5869 | 0.3823 | 0.9901 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Methylglyoxal | 13627.184 | uM | inf | inf | -0.5835 | -0.5835 | 0.0000 | 0.4248 | 0.3872 | 1.0513 | |||
| ZR-75-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14296.189 | uM | inf | inf | -0.9346 | -0.9346 | 0.0000 | 0.5051 | 0.4890 | 0.6639 | |
| ZR-75-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14296.189 | uM | inf | inf | -0.9346 | -0.9346 | 0.0000 | 0.5051 | 0.4890 | 0.6639 | |
| ZR-75-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 12003.145 | uM | 0.56081 | 0.87303 | -0.6361 | -0.6280 | 1.8382 | 0.5574 | 0.9948 | 0.9611 |