Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 11938.157 | uM | inf | inf | 0.3417 | 0.3417 | 0.0000 | 0.4595 | -0.0470 | 0.6995 | |
| HCC1143 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 12112.154 | uM | inf | inf | 0.8713 | 0.8713 | 0.0000 | 0.0797 | -0.0472 | 1.8321 | |
| UACC-812 | HER2amp | Luminal | Ribavirin | 15404.211 | uM | inf | inf | 0.5877 | 0.5877 | 0.0000 | 0.1644 | -0.0476 | 0.5754 | |||
| SUM52PE | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9878.006 | uM | inf | inf | 0.8598 | 0.8598 | 0.0000 | 0.0820 | 0.0476 | 1.3968 | |
| AU565 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10880.155 | uM | inf | inf | 0.9535 | 0.9535 | 0.0000 | 0.0209 | -0.0479 | 1.5205 | |
| AU565 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10880.155 | uM | inf | inf | 0.9535 | 0.9535 | 0.0000 | 0.0209 | -0.0479 | 1.5205 | |
| MDA-MB-453 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7516.065 | uM | inf | inf | 0.8456 | 0.8456 | 0.0000 | 0.0909 | 0.0484 | 1.3224 | |
| HCC1395 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7435.095 | uM | inf | inf | 0.8669 | 0.8669 | 0.0000 | 0.0762 | -0.0489 | 0.8762 | |
| HCC38 | TNBC | Basal B | Selumetinib | MEK | MAPK | 11850.155 | uM | inf | inf | 0.9277 | 0.9277 | 0.0000 | 0.0704 | 0.0489 | 2.1810 | |
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7508.066 | uM | inf | inf | 0.9124 | 0.9124 | 0.0000 | 0.0952 | 0.0492 | 0.8980 | |
| T47D | HR+ | Luminal | PS-1145 | IKK | NFKB | 7543.065 | uM | inf | inf | 0.8542 | 0.8542 | 0.0000 | 0.0523 | 0.0493 | 1.2714 | |
| HCC38 | TNBC | Basal B | GM6001 | MMP | MMP | 7468.096 | uM | inf | inf | 0.8683 | 0.8683 | 0.0000 | 0.0730 | 0.0495 | 1.5683 | |
| HCC2185 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 7462.085 | uM | inf | inf | 0.9501 | 0.9501 | 0.0000 | 0.0232 | 0.0502 | 0.3896 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 11938.161 | uM | inf | inf | 0.4028 | 0.4028 | 0.0000 | 0.2922 | -0.0510 | 0.7388 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7474.09 | uM | inf | inf | 0.9564 | 0.9564 | 0.0000 | -0.0195 | -0.0520 | 2.4405 | |
| MB 157 | Unknown | Unknown | PS-1145 | IKK | NFKB | 7482.065 | uM | inf | inf | 0.9413 | 0.9413 | 0.0000 | 0.0141 | 0.0523 | 2.2390 | |
| BT-474 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 5905.093 | uM | inf | inf | 0.8892 | 0.8892 | 0.0000 | -0.0060 | 0.0525 | 0.9101 | |
| HCC1187 | TNBC | Basal A | PD184352 | MEK | MAPK | 7812.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0727 | 0.0526 | 0.9642 | |
| HCC1187 | TNBC | Basal A | PD184352 | MEK | MAPK | 7812.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0727 | 0.0526 | 0.9642 | |
| HCC38 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7469.066 | uM | inf | inf | 0.9727 | 0.9727 | 0.0000 | 0.0128 | -0.0529 | 2.0057 | |
| ZR75B | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 11939.154 | uM | inf | inf | 0.8647 | 0.8647 | 0.0000 | 0.0937 | 0.0531 | 1.7246 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7474.098 | uM | inf | inf | 1.0223 | 1.0223 | 0.0000 | -0.0080 | -0.0536 | 2.6093 | |
| HCC38 | TNBC | Basal B | Ro 32-0432 | PKC | PKC | 10578.142 | uM | inf | inf | 0.9560 | 0.9560 | 0.0000 | 0.0618 | 0.0539 | 1.8112 | |
| MDA-MB-175-VII | HR+ | Luminal | Celecoxib | COX2 | COX | 10642.136 | uM | inf | inf | 0.5259 | 0.5259 | 0.0000 | 0.1780 | 0.0542 | 0.5193 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7900.018 | uM | inf | inf | 0.5694 | 0.5694 | 0.0000 | 0.2033 | -0.0548 | 0.8304 |