Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | PS-1145 | IKK | NFKB | 7490.065 | uM | inf | inf | 0.9204 | 0.9204 | 0.0000 | -0.0153 | 0.3912 | 2.4816 | |
| HCC1187 | TNBC | Basal A | AG1024 | IGF1R | RTK | 7433.066 | uM | 49.0820 | 39.44790 | 0.7887 | 0.3207 | 4.6933 | -0.0151 | 0.7750 | 1.0755 | |
| BT-549 | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5909.085 | uM | inf | inf | 0.8983 | 0.8983 | 0.0000 | -0.0146 | -0.0760 | 3.0853 | |
| HCC38 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 10268.122 | uM | 0.92849 | 0.80222 | 0.7620 | 0.2528 | 4.8199 | -0.0144 | 0.6866 | 0.6345 | |
| SUM159PT | TNBC | Basal B | Nilotinib | ABL | nRTK | 11057.145 | uM | inf | inf | 1.0062 | 1.0062 | 0.0000 | -0.0143 | -0.1841 | 3.8266 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 10937.149 | uM | 45.2220 | 35.9980 | 0.7333 | 0.3402 | 4.9999 | -0.0142 | 0.8321 | 1.3519 | |
| 184A1 | NM | Basal | GM6001 | MMP | MMP | 5895.096 | uM | inf | inf | 0.9763 | 0.9763 | 0.0000 | -0.0141 | -0.1057 | 1.4232 | |
| MCF7 | HR+ | Luminal | Selumetinib | MEK | MAPK | 10997.155 | uM | inf | inf | 0.9524 | 0.9524 | 0.0000 | -0.0139 | 0.0569 | 1.3159 | |
| MDA-MB-157 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7498.091 | uM | inf | 27.1530 | 0.7131 | 0.7029 | 3.6973 | -0.0137 | 0.8545 | 1.1445 | |
| HCC38 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7469.09 | uM | inf | 79.23380 | 0.8694 | 0.5898 | 4.4214 | -0.0137 | 0.6395 | 1.9867 | |
| MCF12A | NM | Basal B | FTase Inhibitor I | Ftase | MAPK | 12365.167 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0137 | -0.2379 | 2.0273 | |
| HCC1143 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7430.098 | uM | inf | inf | 0.9114 | 0.9114 | 0.0000 | -0.0137 | 0.0580 | 1.9267 | |
| HCC38 | TNBC | Basal B | GW843682X | PLK | PLK | 10578.139 | uM | inf | inf | 0.9988 | 0.9988 | 0.0000 | -0.0137 | -0.1933 | 1.6434 | |
| MCF7 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7875.018 | uM | inf | inf | 0.9316 | 0.9316 | 0.0000 | -0.0136 | 0.3967 | 1.6565 | |
| MDA-MB-361 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 10999.144 | uM | inf | 33.74850 | 0.8575 | 0.8559 | 4.1065 | -0.0135 | 0.6799 | 0.6880 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7475.098 | uM | inf | inf | 1.0092 | 1.0092 | 0.0000 | -0.0133 | -0.1678 | 2.2876 | |
| MDA-MB-134-VI | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 10077.026 | uM | 7.0350 | 7.93710 | 0.4622 | -0.4084 | 4.9480 | -0.0133 | 0.9348 | 0.3999 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 7863.007 | uM | inf | 52.97460 | 0.7011 | 0.5937 | 3.0757 | -0.0133 | 0.8737 | 1.4578 | |
| SK-BR-3 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9759.012 | uM | inf | inf | 0.9728 | 0.9728 | 0.0000 | -0.0132 | -0.0794 | 1.3591 | |
| MDA-MB-415 | HR+ | Luminal | PD184352 | MEK | MAPK | 10938.155 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0131 | -0.0082 | 0.5336 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 10473.137 | uM | inf | inf | 0.8531 | 0.8531 | 0.0000 | -0.0131 | 0.5134 | 1.1322 | |
| MDA-MB-415 | HR+ | Luminal | PD184352 | MEK | MAPK | 10938.155 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0131 | -0.0082 | 0.5336 | |
| BT-483 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9186.049 | uM | 36.87510 | 34.94230 | 0.6087 | 0.1151 | 4.8579 | -0.0129 | 0.8969 | 0.6923 | |
| SUM1315MO2 | TNBC | Basal B | PS-1145 | IKK | NFKB | 9044.065 | uM | inf | inf | 0.8636 | 0.8636 | 0.0000 | -0.0127 | 0.3821 | 0.5944 | |
| MB 157 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 12580.167 | uM | inf | inf | 1.0233 | 1.0233 | 0.0000 | -0.0124 | -0.4459 | 2.1970 |