Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 11854.143 | uM | 402.01920 | 550.84780 | 0.1316 | -0.1064 | 0.6126 | 0.2317 | 0.9890 | 1.1185 | |
| BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 12178.143 | uM | 1053.93470 | 690.84680 | 0.2785 | 0.1751 | 1.0203 | 0.1699 | 0.9078 | 0.7617 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5898.095 | uM | inf | inf | 0.3076 | 0.3076 | 0.0000 | 0.6877 | 0.0000 | 0.6975 | |
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10581.143 | uM | 180.72220 | 1000.00000 | -0.1731 | -0.6881 | 0.5059 | 0.3625 | 0.8258 | 0.9062 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5902.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.0245 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5904.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.6537 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5894.095 | uM | 53.72510 | 62.72890 | -0.1792 | -0.0920 | 1.0901 | 0.3508 | 0.940 | 1.7133 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5899.094 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0167 | -0.1754 | 1.0334 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7793.035 | uM | 7.14650 | 49.68870 | -0.3950 | -0.5513 | 0.3832 | 0.7305 | 0.9781 | 1.2119 | |
| AU565 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5900.095 | uM | inf | 0.31780 | 0.6870 | 0.6767 | 1.2492 | 0.2241 | 0.9272 | 2.1880 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 10385.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0010 | 0.0617 | 0.7986 | |
| 184B5 | NM | Basal | 5-DFUR | TYMS | TYMS | 12566.143 | uM | 303.43380 | 999.99910 | 0.1514 | -0.2734 | 0.3658 | 0.2766 | 0.9906 | 1.6413 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5897.095 | uM | 0.52125 | 0.66097 | -0.3237 | -0.3105 | 2.0341 | 0.8593 | 0.9969 | 1.2197 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5896.095 | uM | 0.24202 | 0.32119 | -0.2838 | -0.2743 | 1.5454 | 0.9106 | 0.9931 | 1.5532 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 9047.017 | uM | 48.1950 | 95.9710 | -0.8459 | -0.8556 | 1.4480 | 0.8094 | 0.9747 | 0.8440 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5895.095 | uM | 0.40767 | 0.41810 | -0.0165 | -0.0219 | 1.6956 | 0.7104 | 0.9924 | 1.4629 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 9118.017 | uM | 78.35630 | 305.35030 | -0.9327 | -1.0000 | 0.8077 | 0.6926 | 0.9801 | 1.0401 | |
| 600MPE | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12224.143 | uM | 0.98003 | 1.61660 | -0.3636 | -0.1428 | 0.5018 | 0.6782 | 0.9151 | 0.8349 | |
| AU565 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 10880.143 | uM | 16.77060 | 49.34150 | -0.1493 | -0.2316 | 0.3527 | 0.4585 | 0.8930 | 1.6077 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7794.017 | uM | 3.63770 | 2.00040 | 0.0921 | 0.3519 | 2.0349 | 0.4369 | 0.8863 | 1.9851 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9035.017 | uM | 234.20810 | 255.89090 | 0.0352 | -0.0320 | 0.6997 | 0.3489 | 0.9930 | 2.2905 | |
| AU565 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5901.095 | uM | inf | 0.0510 | 0.5951 | 0.6004 | 0.9976 | 0.3405 | 0.8985 | 1.9104 | |
| 184A1 | NM | Basal | 5-DFUR | TYMS | TYMS | 12509.143 | uM | 228.63720 | 1000.00000 | -0.2404 | -0.6424 | 0.5600 | 0.2642 | 0.9697 | 1.3392 | |
| BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 12291.143 | uM | 252.60420 | 1000.00000 | -0.2515 | -0.6987 | 0.6355 | 0.3058 | 0.9375 | 0.5621 | |
| BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 12056.143 | uM | 322.2530 | 1000.00000 | 0.0366 | -0.3258 | 0.4431 | 0.2795 | 0.9185 | 1.0075 |