Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 5909.092 | uM | 64.86970 | 405.03060 | 0.6245 | -0.9999 | 0.5998 | 0.0549 | 0.9591 | 3.0314 | |
| BT-549 | TNBC | Basal B | Etoposide | TOP2 | TOP | 5910.074 | uM | 1.67150 | 7.70070 | -0.8162 | -0.8949 | 0.6716 | 0.5562 | 0.9915 | 3.2172 | |
| BT-549 | TNBC | Basal B | Etoposide | TOP2 | TOP | 5909.074 | uM | 3.05470 | 8.37360 | -0.6414 | -0.6889 | 0.8589 | 0.4696 | 0.9957 | 2.8598 | |
| BT-549 | TNBC | Basal B | Everolimus | MTOR | MTOR | 12305.156 | uM | 2.58640 | 0.01021 | 0.4569 | 0.4714 | 0.5167 | 0.3500 | 0.9891 | 2.9137 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 5910.084 | uM | 0.57376 | 0.82215 | -0.8266 | -0.7618 | 2.5733 | 0.4909 | 0.9973 | 3.1096 | |
| BT-549 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 5909.085 | uM | 0.60588 | 0.88538 | -0.6849 | -0.6552 | 2.2075 | 0.4515 | 0.9984 | 3.0853 | |
| BT-549 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 12305.166 | uM | inf | 1000.00000 | 0.7257 | 0.2704 | 0.2845 | 0.0880 | 0.7650 | 2.9556 | |
| BT-549 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 12305.167 | uM | inf | inf | 0.9525 | 0.9525 | 0.0000 | 0.0163 | 0.0596 | 2.8814 | |
| BT-549 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 10261.024 | uM | inf | inf | 0.2887 | 0.2887 | 0.0000 | 0.2246 | 0.0877 | 2.1838 | |
| BT-549 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 9024.016 | uM | 28.2640 | 91.15930 | 0.4348 | -1.0000 | 0.9382 | 0.0677 | 0.9839 | 3.2430 | |
| BT-549 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7804.016 | uM | 16.82910 | 39.59430 | 0.1086 | -1.0000 | 1.2841 | 0.0949 | 0.9923 | 2.3055 | |
| BT-549 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7803.016 | uM | 22.49610 | 82.97740 | 0.3750 | -0.9232 | 0.8014 | 0.0754 | 0.9941 | 2.8300 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7804.04 | uM | 0.00702 | 0.00743 | -0.0788 | -0.1658 | 5.0000 | 0.8506 | 0.9892 | 2.5402 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 10261.024 | uM | 0.00607 | 0.00648 | -0.1576 | -0.1944 | 5.0000 | 0.8906 | 0.9943 | 2.1838 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7803.04 | uM | 0.00496 | 0.00526 | -0.1497 | -0.1683 | 4.9432 | 0.9129 | 0.9968 | 2.8752 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10261.131 | uM | -inf | 0.00002 | -0.3245 | -0.3912 | 0.1000 | 1.0766 | 0.7849 | 2.3992 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9024.075 | uM | 0.00968 | 0.01328 | -0.2851 | -0.1867 | 1.0029 | 0.9846 | 0.9733 | 2.8935 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7803.011 | uM | 0.00759 | 0.00979 | -0.2571 | -0.2190 | 1.4280 | 0.9010 | 0.9933 | 3.0094 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10261.011 | uM | 0.01194 | 0.01438 | -0.1730 | -0.1227 | 1.1802 | 0.7950 | 0.9945 | 2.4327 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7804.011 | uM | 0.01078 | 0.01415 | -0.2591 | -0.2298 | 1.3929 | 0.8749 | 0.9975 | 2.4113 | |
| BT-549 | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 12305.169 | uM | 13.42310 | 14.8160 | 0.0136 | -0.0824 | 1.5455 | 0.1014 | 0.9861 | 2.5786 | ||
| BT-549 | TNBC | Basal B | GM6001 | MMP | MMP | 5909.096 | uM | inf | 5.95550 | 0.8966 | 0.8697 | 0.7287 | 0.0248 | 0.7038 | 3.0117 | |
| BT-549 | TNBC | Basal B | GSK1070916 | AURK | AURK | 10261.001 | uM | 3.66530 | 7.32490 | -0.9301 | -1.0000 | 1.5867 | 0.2924 | 0.9804 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 5910.091 | uM | inf | inf | 0.9825 | 0.9825 | 0.0000 | 0.0118 | 0.2290 | 3.3208 | |
| BT-549 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 5910.07 | uM | inf | 5.58760 | 0.9323 | 0.9007 | 0.3300 | 0.0268 | 0.6225 | 3.3174 |