Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 5910.074 | uM | 0.03103 | 0.04149 | -0.8162 | -0.8169 | 3.3340 | 1.1836 | 1.0000 | 3.2172 | |
| BT-549 | TNBC | Basal B | Bosutinib | Src | nRTK | 12305.17 | uM | 1.55380 | 2.1290 | -0.5499 | -0.5693 | 2.4139 | 0.3647 | 0.9892 | 2.7728 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 9024.075 | uM | 39.44930 | 59.25460 | -0.5688 | -0.5850 | 1.9042 | 0.3888 | 0.9943 | 2.8935 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7803.011 | uM | 33.04150 | 53.67520 | -0.6366 | -0.6683 | 1.7492 | 0.4207 | 0.9973 | 3.0094 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10261.011 | uM | 20.3880 | 32.63670 | -0.4246 | -0.4607 | 1.3880 | 0.4313 | 0.9983 | 2.4327 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7804.011 | uM | 47.18320 | 73.7730 | -0.7090 | -0.7287 | 2.0117 | 0.3853 | 0.9985 | 2.4113 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 10261.026 | uM | inf | inf | 0.9943 | 0.9943 | 0.0000 | -0.0202 | -1.1867 | 2.4866 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7804.042 | uM | inf | 1.1360 | 0.9560 | 0.7915 | 2.6263 | -0.0076 | 0.5868 | 2.4955 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 9024.018 | uM | inf | 0.02553 | 0.8627 | 0.8547 | 0.7831 | 0.0371 | 0.8155 | 2.8306 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7803.042 | uM | 1.64710 | 3.27740 | 0.7927 | -0.6886 | 1.2586 | 0.0007 | 0.8536 | 2.8270 | |
| BT-549 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9024.018 | uM | 196.43820 | 1000.00000 | -0.6766 | -0.9833 | 0.6682 | 0.3932 | 0.8338 | 2.8306 | ||
| BT-549 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 10261.026 | uM | 64.76250 | 644.36690 | -0.7483 | -1.0000 | 0.4782 | 0.4717 | 0.8595 | 2.4866 | ||
| BT-549 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 10261.131 | uM | 1.98770 | 3.79980 | -0.5492 | -0.5789 | 1.1869 | 0.5255 | 0.9939 | 2.3992 | |
| BT-549 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7804.017 | uM | 7.69070 | 13.10720 | -0.7110 | -0.7645 | 1.7402 | 0.4241 | 0.9950 | 2.5963 | |
| BT-549 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7803.017 | uM | 3.6390 | 7.43850 | -0.7208 | -0.7492 | 1.2807 | 0.4846 | 0.9996 | 2.9572 | |
| BT-549 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 10261.121 | uM | 4.34150 | 11.72620 | -0.6572 | -0.8745 | 1.0178 | 0.3079 | 0.9985 | 2.2540 | |
| BT-549 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 12305.155 | uM | inf | inf | 0.8866 | 0.8866 | 0.0000 | 0.1682 | 0.3058 | 2.8841 | |
| BT-549 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 12690.176 | uM | inf | inf | 0.8978 | 0.8978 | 0.0000 | 0.0318 | 0.2447 | 2.3892 | |
| BT-549 | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 12690.174 | uM | 0.15223 | 0.15276 | -0.2592 | -0.0088 | 4.9999 | 0.4483 | 0.9520 | 2.4378 | |
| BT-549 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 10261.002 | uM | 0.00660 | 0.00553 | 0.1803 | 0.1400 | 1.8504 | 0.4965 | 0.9808 | 2.1983 | |
| BT-549 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 12690.002 | uM | 0.00255 | 0.00233 | 0.1072 | 0.0636 | 1.4861 | 0.6150 | 0.9939 | 2.4397 | |
| BT-549 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 10261.121 | uM | 0.12617 | 0.30282 | -0.8923 | -0.7083 | 1.0077 | 0.7467 | 0.9653 | 2.2540 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7803.017 | uM | 0.20903 | 0.46305 | -0.8801 | -0.7455 | 1.1474 | 0.8058 | 0.9886 | 2.9572 | |
| BT-549 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7804.017 | uM | 0.29285 | 0.58804 | -0.9164 | -0.7606 | 1.3264 | 0.7647 | 0.9921 | 2.5963 | |
| BT-549 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 5910.091 | uM | 110.23530 | 600.75210 | 0.6069 | -1.0000 | 0.6479 | 0.0376 | 0.9246 | 3.3208 |