Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5906.095 | uM | inf | inf | 1.0129 | 1.0129 | 0.0000 | 0.0481 | 0.0000 | 0.6731 | |
| BT-474 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5905.095 | uM | inf | inf | 0.9541 | 0.9541 | 0.0000 | 0.0237 | 0.0563 | 0.9590 | |
| BT-474 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 5905.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0377 | -5.6704 | 0.8461 | |
| BT-474 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 5906.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0021 | -0.0022 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 5906.067 | uM | inf | inf | 0.9890 | 0.9890 | 0.0000 | -0.0331 | -0.7588 | 0.6838 | |
| BT-474 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 5905.067 | uM | inf | 26.78340 | 0.7087 | 0.7086 | 4.9803 | 0.0276 | 0.9043 | 0.7991 | |
| BT-474 | HER2amp | Luminal | QNZ | NFkB | NFKB | 5905.096 | uM | 0.02904 | 0.03534 | -0.4953 | -0.3033 | 2.4165 | 0.6682 | 0.9839 | 0.9091 | |
| BT-474 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 12178.144 | uM | inf | inf | 0.6501 | 0.6501 | 0.0000 | 0.2306 | 0.3846 | 0.7891 | |
| BT-474 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 12056.144 | uM | inf | inf | 0.7102 | 0.7102 | 0.0000 | 0.1537 | 0.4982 | 0.9738 | |
| BT-474 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 12291.168 | uM | 6.40940 | 16.7950 | -0.9999 | -1.0000 | 1.1405 | 0.4929 | 0.8676 | 0.4466 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 12178.155 | uM | inf | inf | 0.7564 | 0.7564 | 0.0000 | 0.1748 | 0.0109 | 0.8489 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 12291.155 | uM | inf | inf | 0.8945 | 0.8945 | 0.0000 | -0.0163 | 0.0368 | 0.4532 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 12056.155 | uM | inf | inf | 0.6967 | 0.6967 | 0.0000 | 0.1421 | 0.3782 | 0.8251 | |
| BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12291.165 | uM | 0.08918 | 0.66991 | -0.9980 | -1.0000 | 0.5448 | 0.8274 | 0.8520 | 0.5602 | |
| BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12056.158 | uM | 0.72952 | 3.1890 | -0.8607 | -1.0000 | 0.7448 | 0.5557 | 0.9726 | 0.9929 | |
| BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12178.158 | uM | 1.57950 | 4.28540 | -0.8896 | -1.0000 | 1.1007 | 0.4947 | 0.9798 | 0.7379 | |
| BT-474 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7797.068 | uM | 0.00268 | 0.00278 | -0.1887 | -0.0334 | 1.6668 | 0.8666 | 0.8991 | 0.3664 | |
| BT-474 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7798.068 | uM | inf | 0.00634 | 0.4293 | 0.5223 | 2.3948 | 0.3712 | 0.9582 | 1.2859 | |
| BT-474 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 5906.069 | uM | 0.00522 | 0.00452 | -0.0307 | 0.1007 | 1.5661 | 0.6070 | 0.9691 | 0.7682 | |
| BT-474 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5905.085 | uM | 25.84930 | 58.21470 | -0.9937 | -1.0000 | 1.3532 | 0.3254 | 0.9707 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5906.084 | uM | 459.90660 | 523.65990 | -0.1940 | -0.3051 | 3.6692 | 0.0443 | 0.9888 | 0.5452 | |
| BT-474 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5905.067 | uM | 10.87560 | 13.54810 | -0.9993 | -1.0000 | 5.0000 | 0.3691 | 0.9961 | 0.7991 | |
| BT-474 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5906.067 | uM | 12.96240 | 16.14770 | -0.9982 | -1.0000 | 5.0000 | 0.3347 | 0.9970 | 0.6838 | |
| BT-474 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 5905.096 | uM | 63.96990 | 112.68570 | 0.6808 | -0.3704 | 0.9791 | 0.0316 | 0.8092 | 0.9091 | ||
| BT-474 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9157.002 | uM | 0.01170 | 0.01401 | -0.2154 | -0.1440 | 1.4006 | 0.6817 | 0.9924 | 0.9306 |