Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 10755.147 | uM | 19.5320 | 22.52470 | -0.4836 | -0.4915 | 4.8025 | 0.1825 | 0.9064 | 0.6156 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 5911.066 | uM | 22.79660 | 62.92350 | -0.0608 | -1.0000 | 1.0820 | 0.2363 | 0.690 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 5912.066 | uM | 63.29120 | 144.88630 | 0.4730 | -0.9999 | 1.3264 | 0.0453 | 0.9473 | 1.0480 | |
| CAMA-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 10755.147 | uM | 7.28810 | 12.43120 | -0.7676 | -0.7973 | 1.7856 | 0.3955 | 0.9776 | 0.6156 | |
| CAMA-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 12070.147 | uM | 2.91340 | 6.480 | -0.9631 | -0.9894 | 1.3654 | 0.4675 | 0.9940 | 0.9269 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 10755.087 | uM | 0.05525 | 0.12174 | -0.9621 | -0.9486 | 1.3464 | 0.8971 | 0.9851 | 0.7400 | |
| CAMA-1 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 10473.087 | uM | 0.10010 | 0.20964 | -0.8136 | -0.7828 | 1.2745 | 0.6739 | 0.9965 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9210.011 | uM | 8.33070 | 30.68990 | -0.9617 | -1.0000 | 0.8425 | 0.5433 | 0.9535 | 0.9440 | |
| CAMA-1 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 10755.147 | uM | 0.88951 | 1.3670 | -0.9986 | -0.9482 | 2.4748 | 0.6639 | 0.9797 | 0.6156 | |
| CAMA-1 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 12070.147 | uM | 0.54020 | 0.87409 | -0.9845 | -0.9901 | 2.2690 | 0.7124 | 0.9890 | 0.9269 | |
| CAMA-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 10755.152 | uM | inf | inf | 0.5641 | 0.5641 | 0.0000 | 0.2866 | -0.0260 | 0.5859 | |
| CAMA-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 12070.159 | uM | 39.4710 | 14.80140 | 0.4207 | 0.2638 | 0.7644 | 0.1539 | 0.7379 | 0.9846 | |
| CAMA-1 | HR+ | Luminal | PD 98059 | MEK | MAPK | 10473.136 | uM | 120.37030 | 718.98220 | 0.5383 | -0.9958 | 0.6131 | 0.0695 | 0.9347 | 1.3186 | |
| CAMA-1 | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 10473.1 | uM | 15.52310 | 23.19590 | -0.9029 | -1.0000 | 2.7353 | 0.2888 | 0.9340 | 1.3652 | |
| CAMA-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 12070.155 | uM | inf | inf | 0.8551 | 0.8551 | 0.0000 | 0.0592 | -0.0020 | 1.1729 | |
| CAMA-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 12070.155 | uM | inf | inf | 0.8551 | 0.8551 | 0.0000 | 0.0592 | -0.0020 | 1.1729 | |
| CAMA-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 10755.146 | uM | inf | inf | 0.7200 | 0.7200 | 0.0000 | 0.1412 | 0.2466 | 0.8035 | |
| CAMA-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 10755.146 | uM | inf | inf | 0.7200 | 0.7200 | 0.0000 | 0.1412 | 0.2466 | 0.8035 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5912.095 | uM | inf | inf | 0.7782 | 0.7782 | 0.0000 | 0.1986 | 0.5533 | 0.9981 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5911.094 | uM | 0.25033 | 0.05775 | 0.4743 | 0.4915 | 2.7768 | 0.4432 | 0.8140 | 1.0146 | |
| CAMA-1 | HR+ | Luminal | PS-1145 | IKK | NFKB | 5912.065 | uM | inf | inf | 0.6655 | 0.6655 | 0.0000 | 0.0962 | 0.5444 | 1.1516 | |
| CAMA-1 | HR+ | Luminal | PS-1145 | IKK | NFKB | 5911.065 | uM | 14728.7992 | 1000.00000 | 0.5720 | 0.2713 | 0.2909 | 0.1606 | 0.6932 | 0.7592 | |
| CAMA-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 5912.067 | uM | inf | inf | 0.8672 | 0.8672 | 0.0000 | 0.0876 | -0.0304 | 1.1725 | |
| CAMA-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 5911.067 | uM | 107.65760 | 348.76790 | 0.3301 | -0.9996 | 0.9344 | 0.0672 | 0.9816 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Ribavirin | 15348.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0410 | -5.7835 | 0.7490 |