Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | Nelfinavir | 13099.174 | uM | 8.33740 | 12.98640 | -0.8248 | -1.0000 | 2.4791 | 0.2096 | 0.9823 | 0.9441 | |||
| HCC1143 | TNBC | Basal A | Nilotinib | ABL | nRTK | 12112.145 | uM | inf | inf | 0.9353 | 0.9353 | 0.0000 | 0.0338 | 0.0179 | 1.9247 | |
| HCC1143 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 12112.159 | uM | 1.65580 | 2.04930 | -0.8704 | -0.8462 | 4.6458 | 0.6203 | 0.9973 | 1.8609 | |
| HCC1143 | TNBC | Basal A | NU6102 | CDK1/2 | CDK | 12112.147 | uM | 15.53550 | 42.20730 | -0.2561 | -1.0000 | 1.0992 | 0.2003 | 0.9510 | 1.8559 | |
| HCC1143 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 7430.066 | uM | 43.83610 | 41.89710 | 0.2310 | 0.0707 | 3.3704 | 0.0403 | 0.9913 | 1.7623 | |
| HCC1143 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 12112.147 | uM | 3.56240 | 6.1440 | -0.5451 | -0.5766 | 1.4072 | 0.3726 | 0.9979 | 1.8559 | |
| HCC1143 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 7430.086 | uM | 0.04702 | 0.08855 | -0.4404 | -0.2887 | 0.7201 | 0.5752 | 0.9725 | 1.7884 | |
| HCC1143 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7810.011 | uM | 17.43650 | 33.96740 | -0.9111 | -0.9647 | 1.6118 | 0.4304 | 0.9942 | 0.9243 | |
| HCC1143 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9233.12 | uM | 25.14560 | 41.16370 | -0.8425 | -0.8492 | 2.0140 | 0.3699 | 0.9982 | 1.1442 | |
| HCC1143 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 12112.147 | uM | 0.58530 | 2.00730 | -0.7033 | -0.8291 | 0.7933 | 0.5344 | 0.9882 | 1.8559 | |
| HCC1143 | TNBC | Basal A | PD 98059 | MEK | MAPK | 12112.159 | uM | 305.83130 | 999.73550 | 0.6289 | -0.3720 | 0.4696 | 0.0840 | 0.7922 | 1.8609 | |
| HCC1143 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 7430.093 | uM | 13.84870 | 21.0130 | -0.0291 | -0.5045 | 1.6733 | 0.0825 | 0.9957 | 1.9432 | |
| HCC1143 | TNBC | Basal A | PD184352 | MEK | MAPK | 12112.155 | uM | inf | 999.96340 | 0.7985 | 0.1935 | 0.3134 | 0.0636 | 0.7788 | 1.7965 | |
| HCC1143 | TNBC | Basal A | PD184352 | MEK | MAPK | 12112.155 | uM | inf | 999.96340 | 0.7985 | 0.1935 | 0.3134 | 0.0636 | 0.7788 | 1.7965 | |
| HCC1143 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7430.095 | uM | inf | inf | 0.8459 | 0.8459 | 0.0000 | 0.1262 | 0.4872 | 1.9390 | |
| HCC1143 | TNBC | Basal A | PS-1145 | IKK | NFKB | 7430.065 | uM | inf | inf | 0.9420 | 0.9420 | 0.0000 | -0.0190 | -0.3143 | 1.9263 | |
| HCC1143 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 7430.067 | uM | inf | 35.48870 | 0.8725 | 0.8724 | 4.9993 | -0.0048 | 0.5801 | 1.9308 | |
| HCC1143 | TNBC | Basal A | QNZ | NFkB | NFKB | 7430.096 | uM | inf | 0.02096 | 0.5504 | 0.5766 | 0.4766 | 0.2374 | 0.9622 | 2.0162 | |
| HCC1143 | TNBC | Basal A | Ribavirin | 15349.211 | uM | inf | inf | 0.8845 | 0.8845 | 0.0000 | 0.0438 | -0.0616 | 1.2538 | |||
| HCC1143 | TNBC | Basal A | SB-3CT | MMP2/9 | MMP | 12112.144 | uM | 356.54910 | 1000.00000 | 0.6439 | -0.2848 | 0.4371 | 0.0966 | 0.6441 | 1.9163 | |
| HCC1143 | TNBC | Basal A | Selumetinib | MEK | MAPK | 12112.155 | uM | inf | 0.16467 | 0.5706 | 0.6237 | 1.4639 | 0.1565 | 0.9624 | 1.7965 | |
| HCC1143 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 12112.158 | uM | 14.8090 | 23.94180 | -0.8320 | -1.0000 | 2.2869 | 0.2578 | 0.9630 | 1.8430 | |
| HCC1143 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7809.068 | uM | 1.18010 | 0.00577 | 0.3535 | 0.3928 | 0.2895 | 0.4238 | 0.7314 | 1.7208 | |
| HCC1143 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7430.085 | uM | 57.30850 | 69.22010 | -0.7847 | -0.7854 | 5.0000 | 0.1886 | 0.9971 | 1.9592 | |
| HCC1143 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7430.067 | uM | 8.47310 | 12.95630 | -0.8826 | -0.8843 | 2.3979 | 0.3564 | 0.9986 | 1.9308 |