Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Etoposide | TOP2 | TOP | 2.67 | uM | 7537.074 | 0.4484 | 0.3415 | 2.0080 | |
| SUM229PE | TNBC | - | Etoposide | TOP2 | TOP | 13.3 | uM | 7537.074 | 0.1726 | -0.1661 | 2.0080 | |
| SUM229PE | TNBC | - | Etoposide | TOP2 | TOP | 66.7 | uM | 7537.074 | 0.0661 | -0.4832 | 2.0080 | |
| SUM229PE | TNBC | - | Etoposide | TOP2 | TOP | 333 | uM | 7537.074 | 0.0563 | -0.5228 | 2.0080 | |
| SUM52PE | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7541.074 | 1.0317 | 1.0477 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7541.074 | 0.9568 | 0.9343 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7541.074 | 1.0246 | 1.0371 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7541.074 | 0.9481 | 0.9209 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7541.074 | 0.9714 | 0.9566 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7541.074 | 0.6649 | 0.4688 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7541.074 | 0.3100 | -0.1752 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7541.074 | 0.2302 | -0.3415 | 1.3223 | |
| SUM52PE | HR+ | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7541.074 | 0.1492 | -0.5256 | 1.3223 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7542.074 | 0.9988 | 0.9983 | 1.4673 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7542.074 | 0.9775 | 0.9692 | 1.4673 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7542.074 | 0.9911 | 0.9879 | 1.4673 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7542.074 | 0.8865 | 0.8424 | 1.4673 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7542.074 | 0.7867 | 0.6983 | 1.4673 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7542.074 | 0.3790 | 0.0324 | 1.4673 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7542.074 | 0.2388 | -0.2463 | 1.4673 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7542.074 | 0.2424 | -0.2387 | 1.4673 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7542.074 | 0.2213 | -0.2845 | 1.4673 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7543.074 | 0.9452 | 0.9128 | 1.2642 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7543.074 | 1.0049 | 1.0077 | 1.2642 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7543.074 | 0.9489 | 0.9186 | 1.2642 |