Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7492.074 | 0.5648 | 0.3383 | 1.4222 | |
| MCF7 | HR+ | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7492.074 | 0.3566 | -0.0314 | 1.4222 | |
| MCF7 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7493.074 | 1.0332 | 1.0574 | 1.1549 | |
| MCF7 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7493.074 | 0.9356 | 0.8880 | 1.1549 | |
| MCF7 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7493.074 | 0.9888 | 0.9805 | 1.1549 | |
| MCF7 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7493.074 | 0.9229 | 0.8658 | 1.1549 | |
| MCF7 | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7493.074 | 0.8445 | 0.7277 | 1.1549 | |
| MCF7 | HR+ | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7493.074 | 0.7064 | 0.4802 | 1.1549 | |
| MCF7 | HR+ | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7493.074 | 0.5974 | 0.2803 | 1.1549 | |
| MCF7 | HR+ | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7493.074 | 0.4519 | 0.0054 | 1.1549 | |
| MCF7 | HR+ | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7493.074 | 0.3788 | -0.1370 | 1.1549 | |
| MDA-MB-134-VI | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.000853 | uM | 7494.074 | 0.9785 | 0.9367 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.00427 | uM | 7494.074 | 0.9812 | 0.9445 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.0213 | uM | 7494.074 | 1.0135 | 1.0401 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.107 | uM | 7494.074 | 1.0038 | 1.0113 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Etoposide | TOP2 | TOP | 0.533 | uM | 7494.074 | 0.8039 | 0.4485 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Etoposide | TOP2 | TOP | 2.67 | uM | 7494.074 | 0.8620 | 0.6060 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Etoposide | TOP2 | TOP | 13.3 | uM | 7494.074 | 0.6475 | 0.0521 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Etoposide | TOP2 | TOP | 66.7 | uM | 7494.074 | 0.5182 | -0.2431 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Etoposide | TOP2 | TOP | 333 | uM | 7494.074 | 0.4219 | -0.4413 | 0.6767 | |
| MDA-MB-157 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.000853 | uM | 7495.074 | 1.0035 | 1.0060 | 1.1729 | |
| MDA-MB-157 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.00427 | uM | 7495.074 | 0.9690 | 0.9471 | 1.1729 | |
| MDA-MB-157 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.0213 | uM | 7495.074 | 1.0140 | 1.0238 | 1.1729 | |
| MDA-MB-157 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.107 | uM | 7495.074 | 0.7543 | 0.5726 | 1.1729 | |
| MDA-MB-157 | TNBC | Basal B | Etoposide | TOP2 | TOP | 0.533 | uM | 7495.074 | 0.6431 | 0.3727 | 1.1729 |