Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 3.68 | uM | 7491.078 | 0.0051 | -0.9986 | 0.7238 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 18.4 | uM | 7491.078 | 0.0057 | -0.9984 | 0.7238 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 92 | uM | 7491.078 | 0.0003 | -1.0000 | 0.7238 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 10061.121 | 1.0856 | 1.0866 | 1.9364 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 10061.121 | 0.9350 | 0.9318 | 1.9364 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 10061.121 | 1.0315 | 1.0323 | 1.9364 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 10061.121 | 0.8397 | 0.8275 | 1.9364 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.147 | uM | 10061.121 | 0.5658 | 0.4904 | 1.9364 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.736 | uM | 10061.121 | 0.0194 | -0.7392 | 1.9364 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 3.68 | uM | 10061.121 | 0.0103 | -0.8120 | 1.9364 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 18.4 | uM | 10061.121 | 0.0079 | -0.8360 | 1.9364 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 92 | uM | 10061.121 | 0.0071 | -0.8447 | 1.9364 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.000221 | uM | 7875.007 | 1.1010 | 1.1334 | 1.4906 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0011 | uM | 7875.007 | 1.0837 | 1.1108 | 1.4906 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00552 | uM | 7875.007 | 1.0457 | 1.0609 | 1.4906 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0276 | uM | 7875.007 | 1.0130 | 1.0174 | 1.4906 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.138 | uM | 7875.007 | 0.9093 | 0.8764 | 1.4906 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.69 | uM | 7875.007 | 0.1840 | -0.3575 | 1.4906 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 3.45 | uM | 7875.007 | 0.3446 | -0.0214 | 1.4906 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 17.2 | uM | 7875.007 | 0.3095 | -0.0893 | 1.4906 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7875.007 | 0.0336 | -0.7945 | 1.4906 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9583.121 | 1.1125 | 1.2105 | 1.0648 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 9583.121 | 1.0284 | 1.0533 | 1.0648 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9583.121 | 1.0684 | 1.1282 | 1.0648 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9583.121 | 1.0323 | 1.0606 | 1.0648 |