Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 92 | uM | 7488.078 | 0.0276 | -0.8135 | 1.5130 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 0.000221 | uM | 7872.007 | 0.9295 | 0.9165 | 1.7126 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 0.0011 | uM | 7872.007 | 0.8448 | 0.8125 | 1.7126 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 0.00552 | uM | 7872.007 | 0.9653 | 0.9592 | 1.7126 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 0.0276 | uM | 7872.007 | 2.2480 | 2.2096 | 1.7126 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 0.138 | uM | 7872.007 | 0.7853 | 0.7367 | 1.7126 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 0.69 | uM | 7872.007 | 0.6834 | 0.6014 | 1.7126 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 3.45 | uM | 7872.007 | 0.0003 | -0.9824 | 1.7126 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 17.2 | uM | 7872.007 | 0.0003 | -0.9824 | 1.7126 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7872.007 | 2.4960 | 2.4119 | 1.7126 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9566.121 | 1.1800 | 1.1486 | 2.3089 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 9566.121 | 0.9700 | 0.9738 | 2.3089 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9566.121 | 1.0063 | 1.0055 | 2.3089 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9566.121 | 0.9530 | 0.9588 | 2.3089 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 0.147 | uM | 9566.121 | 0.7626 | 0.7785 | 2.3089 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 0.736 | uM | 9566.121 | 0.4696 | 0.4416 | 2.3089 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9566.121 | 0.0172 | -0.6559 | 2.3089 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9566.121 | 0.0137 | -0.6879 | 2.3089 | |
| MCF 10F | NM | - | Doxorubicin | TOP2 | TOP | 92 | uM | 9566.121 | 0.0091 | -0.7383 | 2.3089 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 7491.078 | 0.9249 | 0.7955 | 0.7238 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 7491.078 | 0.9252 | 0.7962 | 0.7238 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 7491.078 | 0.8369 | 0.5638 | 0.7238 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 7491.078 | 0.6806 | 0.1754 | 0.7238 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.147 | uM | 7491.078 | 0.5804 | -0.0568 | 0.7238 | |
| MCF12A | NM | Basal B | Doxorubicin | TOP2 | TOP | 0.736 | uM | 7491.078 | 0.0449 | -0.9725 | 0.7238 |