Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 1.33 | uM | 10644.146 | 0.9413 | 0.8072 | 0.5967 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 6.67 | uM | 10644.146 | 0.7203 | 0.1541 | 0.5967 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 33.3 | uM | 10644.146 | 0.9569 | 0.8577 | 0.5967 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10874.155 | 0.9488 | 0.8744 | 0.8099 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10874.155 | 1.0445 | 1.1104 | 0.8099 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10874.155 | 0.9729 | 0.9332 | 0.8099 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10874.155 | 1.0254 | 1.0630 | 0.8099 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10874.155 | 0.9268 | 0.8209 | 0.8099 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.267 | uM | 10874.155 | 0.8933 | 0.7400 | 0.8099 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 1.33 | uM | 10874.155 | 0.3520 | -0.4490 | 0.8099 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 6.67 | uM | 10874.155 | 0.5240 | -0.0994 | 0.8099 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 33.3 | uM | 10874.155 | 0.8014 | 0.5216 | 0.8099 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12220.155 | 1.0007 | 1.0028 | 0.4858 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12220.155 | 0.9051 | 0.6289 | 0.4858 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12220.155 | 0.9678 | 0.8697 | 0.4858 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12220.155 | 0.9542 | 0.8158 | 0.4858 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12220.155 | 0.8903 | 0.5744 | 0.4858 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.267 | uM | 12220.155 | 0.7572 | 0.1283 | 0.4858 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 1.33 | uM | 12220.155 | 0.5395 | -0.4385 | 0.4858 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 6.67 | uM | 12220.155 | 0.8525 | 0.4401 | 0.4858 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 33.3 | uM | 12220.155 | 0.8207 | 0.3317 | 0.4858 | |
| SK-BR-3 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11851.155 | 0.8992 | 0.8682 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 11851.155 | 0.9642 | 0.9538 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 11851.155 | 0.9294 | 0.9082 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11851.155 | 1.0068 | 1.0087 | 1.5585 |