Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 11055.155 | 0.3973 | 0.1781 | 1.7439 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10996.155 | 1.0329 | 1.0955 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10996.155 | 0.9928 | 0.9794 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10996.155 | 0.9750 | 0.9283 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10996.155 | 0.9907 | 0.9731 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10996.155 | 0.8890 | 0.6879 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10996.155 | 0.9209 | 0.7758 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10996.155 | 0.4668 | -0.3334 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10996.155 | 0.8940 | 0.7016 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10996.155 | 0.6749 | 0.1344 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12192.155 | 0.9286 | 0.8106 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12192.155 | 1.0120 | 1.0322 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12192.155 | 0.8524 | 0.6140 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12192.155 | 1.0311 | 1.0840 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12192.155 | 0.8408 | 0.5847 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12192.155 | 0.6408 | 0.1005 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12192.155 | 0.3637 | -0.4854 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12192.155 | 0.8301 | 0.5577 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12192.155 | 0.7421 | 0.3402 | 0.7451 | |
| HCC3153 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10937.155 | 0.9744 | 0.9609 | 1.3142 | |
| HCC3153 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10937.155 | 0.9708 | 0.9553 | 1.3142 | |
| HCC3153 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10937.155 | 0.9378 | 0.9046 | 1.3142 | |
| HCC3153 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10937.155 | 0.9542 | 0.9299 | 1.3142 | |
| HCC3153 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10937.155 | 0.9084 | 0.8591 | 1.3142 | |
| HCC3153 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.267 | uM | 10937.155 | 0.8508 | 0.7686 | 1.3142 |