Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12239.155 | 0.9998 | 0.9998 | 2.1474 | |
| HCC1806 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12239.155 | 1.0006 | 1.0005 | 2.1474 | |
| HCC1806 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12239.155 | 1.0072 | 1.0067 | 2.1474 | |
| HCC1806 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12239.155 | 0.9386 | 0.9418 | 2.1474 | |
| HCC1806 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.267 | uM | 12239.155 | 0.9668 | 0.9688 | 2.1474 | |
| HCC1806 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 1.33 | uM | 12239.155 | 0.4763 | 0.4159 | 2.1474 | |
| HCC1806 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 12239.155 | 0.9837 | 0.9848 | 2.1474 | |
| HCC1806 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 12239.155 | 0.8959 | 0.9002 | 2.1474 | |
| HCC1937 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11849.155 | 1.0099 | 1.0132 | 1.4975 | |
| HCC1937 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.000427 | uM | 11849.155 | 0.9928 | 0.9904 | 1.4975 | |
| HCC1937 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.00213 | uM | 11849.155 | 1.0317 | 1.0421 | 1.4975 | |
| HCC1937 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11849.155 | 0.9645 | 0.9524 | 1.4975 | |
| HCC1937 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11849.155 | 0.9416 | 0.9212 | 1.4975 | |
| HCC1937 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.267 | uM | 11849.155 | 0.9333 | 0.9100 | 1.4975 | |
| HCC1937 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 1.33 | uM | 11849.155 | 0.4490 | 0.1718 | 1.4975 | |
| HCC1937 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 11849.155 | 0.7036 | 0.5815 | 1.4975 | |
| HCC1937 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 11849.155 | 0.8722 | 0.8255 | 1.4975 | |
| HCC1954 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11055.155 | 0.9167 | 0.9026 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.000427 | uM | 11055.155 | 0.9813 | 0.9785 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.00213 | uM | 11055.155 | 0.9963 | 0.9957 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11055.155 | 1.0695 | 1.0786 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11055.155 | 0.6343 | 0.5405 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.267 | uM | 11055.155 | 0.3267 | 0.0531 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 1.33 | uM | 11055.155 | 0.2085 | -0.1861 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 11055.155 | 0.2755 | -0.0451 | 1.7439 |