Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10938.155 | 0.8922 | 0.6152 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12333.155 | 1.0385 | 1.1347 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12333.155 | 1.0202 | 1.0702 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12333.155 | 0.9447 | 0.8128 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12333.155 | 0.9358 | 0.7835 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12333.155 | 0.8941 | 0.6485 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12333.155 | 0.7942 | 0.3433 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12333.155 | 0.3439 | -0.6835 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12333.155 | 0.9579 | 0.8567 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12333.155 | 0.9365 | 0.7859 | 0.5790 | |
| MDA-MB-453 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12414.155 | 0.9780 | 0.9645 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12414.155 | 0.9139 | 0.8602 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12414.155 | 0.9798 | 0.9675 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12414.155 | 0.9027 | 0.8417 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12414.155 | 0.9236 | 0.8760 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12414.155 | 0.2135 | -0.4232 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12414.155 | 0.1580 | -0.5472 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12414.155 | 0.1913 | -0.4719 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12414.155 | 0.2002 | -0.4522 | 1.2420 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10644.146 | 1.0316 | 1.1070 | 0.5967 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10644.146 | 0.9586 | 0.8632 | 0.5967 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10644.146 | 1.0073 | 1.0245 | 0.5967 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10644.146 | 0.9824 | 0.9413 | 0.5967 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10644.146 | 0.9795 | 0.9317 | 0.5967 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.267 | uM | 10644.146 | 0.9646 | 0.8829 | 0.5967 |