Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9186.121 | 0.5344 | -0.0532 | 0.8379 | |
| BT-483 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9186.121 | 0.6965 | 0.2988 | 0.8379 | |
| BT-483 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 9186.121 | 0.3638 | -0.4016 | 0.8379 | |
| BT-549 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 10261.121 | 0.9567 | 0.9611 | 2.2540 | |
| BT-549 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 10261.121 | 1.0202 | 1.0178 | 2.2540 | |
| BT-549 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 10261.121 | 0.9506 | 0.9556 | 2.2540 | |
| BT-549 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 10261.121 | 0.8118 | 0.8233 | 2.2540 | |
| BT-549 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 0.147 | uM | 10261.121 | 0.5639 | 0.5512 | 2.2540 | |
| BT-549 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 0.736 | uM | 10261.121 | 0.0640 | -0.4092 | 2.2540 | |
| BT-549 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 3.68 | uM | 10261.121 | 0.0935 | -0.3010 | 2.2540 | |
| BT-549 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 18.4 | uM | 10261.121 | 0.0205 | -0.6437 | 2.2540 | |
| BT-549 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 92 | uM | 10261.121 | 0.0014 | -0.8923 | 2.2540 | |
| CAMA-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.000236 | uM | 9210.121 | 1.0878 | 1.1966 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00118 | uM | 9210.121 | 0.9685 | 0.9298 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.00589 | uM | 9210.121 | 1.1456 | 1.3271 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.0294 | uM | 9210.121 | 1.1239 | 1.2783 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.147 | uM | 9210.121 | 0.9266 | 0.8370 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 0.736 | uM | 9210.121 | 0.2075 | -0.6536 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 3.68 | uM | 9210.121 | 0.0574 | -0.9173 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 18.4 | uM | 9210.121 | 0.0459 | -0.9355 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 92 | uM | 9210.121 | 0.0055 | -0.9940 | 0.8970 | |
| HBL-100 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.000221 | uM | 7808.043 | 0.9809 | 0.9839 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.0011 | uM | 7808.043 | 0.9510 | 0.9584 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.00552 | uM | 7808.043 | 0.9656 | 0.9709 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 0.0276 | uM | 7808.043 | 0.6561 | 0.6767 | 2.3907 |