Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10999.155 | 1.0325 | 1.0888 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10999.155 | 0.9748 | 0.9320 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10999.155 | 0.9769 | 0.9377 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10999.155 | 0.9829 | 0.9537 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10999.155 | 0.7615 | 0.3819 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10999.155 | 0.2428 | -0.7070 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10999.155 | 1.2837 | 1.8066 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 10999.155 | 0.6592 | 0.1363 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12379.155 | 1.0013 | 1.0071 | 0.3793 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12379.155 | 1.0281 | 1.1514 | 0.3793 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12379.155 | 1.0203 | 1.1090 | 0.3793 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12379.155 | 0.9758 | 0.8751 | 0.3793 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12379.155 | 0.9270 | 0.6376 | 0.3793 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 12379.155 | 0.5323 | -0.6206 | 0.3793 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 12379.155 | 0.1682 | -0.9818 | 0.3793 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 12379.155 | 0.2281 | -0.9594 | 0.3793 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 12379.155 | 0.3381 | -0.8854 | 0.3793 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10938.155 | 0.8913 | 0.6119 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10938.155 | 1.2371 | 1.9798 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10938.155 | 1.2246 | 1.9238 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10938.155 | 1.2054 | 1.8383 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10938.155 | 1.1688 | 1.6790 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 10938.155 | 0.8408 | 0.4450 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 10938.155 | 0.2842 | -0.8108 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 10938.155 | 0.9801 | 0.9260 | 0.5336 |