Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11936.155 | 0.9671 | 0.9107 | 0.7332 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11936.155 | 1.0061 | 1.0167 | 0.7332 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 11936.155 | 0.8472 | 0.5952 | 0.7332 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 11936.155 | 0.3908 | -0.4448 | 0.7332 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 11936.155 | 0.7881 | 0.4454 | 0.7332 | |
| HCC1428 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 11936.155 | 0.8843 | 0.6912 | 0.7332 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10872.155 | 0.9491 | 0.9329 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10872.155 | 1.0545 | 1.0706 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10872.155 | 0.9263 | 0.9023 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10872.155 | 1.0148 | 1.0194 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10872.155 | 0.9056 | 0.8744 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.267 | uM | 10872.155 | 0.7963 | 0.7231 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 1.33 | uM | 10872.155 | 0.3640 | 0.0325 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 10872.155 | 0.5280 | 0.3171 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 10872.155 | 0.7734 | 0.6906 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12523.155 | 0.9788 | 0.9599 | 1.0583 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12523.155 | 0.9806 | 0.9633 | 1.0583 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12523.155 | 1.0003 | 1.0006 | 1.0583 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12523.155 | 0.9870 | 0.9755 | 1.0583 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12523.155 | 0.9988 | 0.9978 | 1.0583 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 0.267 | uM | 12523.155 | 0.9809 | 0.9638 | 1.0583 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 1.33 | uM | 12523.155 | 0.5265 | 0.0909 | 1.0583 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 12523.155 | 0.6871 | 0.4029 | 1.0583 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 12523.155 | 0.7835 | 0.5882 | 1.0583 | |
| HCC1806 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12239.155 | 0.9530 | 0.9557 | 2.1474 |