Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 10151.034 | 1.0484 | 1.3158 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 10151.034 | 0.7998 | 0.0007 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 10151.034 | 0.7626 | -0.1367 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 10151.034 | 0.5472 | -0.6914 | 0.3226 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 10267.121 | 1.0665 | 1.3368 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 10267.121 | 1.1296 | 1.6853 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 10267.121 | 1.0039 | 1.0188 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 10267.121 | 1.1474 | 1.7889 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 10267.121 | 1.0860 | 1.4417 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 10267.121 | 1.1059 | 1.5514 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 10267.121 | 0.8722 | 0.4367 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 10267.121 | 0.6239 | -0.3608 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 10267.121 | 0.5450 | -0.5391 | 0.4135 | |
| UACC-893 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 9933.034 | 0.9705 | 0.8962 | 0.5612 | |
| UACC-893 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 9933.034 | 1.1647 | 1.6245 | 0.5612 | |
| UACC-893 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 9933.034 | 0.9795 | 0.9275 | 0.5612 | |
| UACC-893 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 9933.034 | 1.0635 | 1.2320 | 0.5612 | |
| UACC-893 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 9933.034 | 1.1403 | 1.5270 | 0.5612 | |
| UACC-893 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 9933.034 | 1.0638 | 1.2329 | 0.5612 | |
| UACC-893 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 9933.034 | 1.1417 | 1.5328 | 0.5612 | |
| UACC-893 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 9933.034 | 1.2746 | 2.0816 | 0.5612 | |
| UACC-893 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 9933.034 | 0.4400 | -0.5368 | 0.5612 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7931.007 | 1.0016 | 1.0022 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7931.007 | 0.9911 | 0.9878 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7931.007 | 1.0551 | 1.0751 | 1.4557 |