Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11851.155 | 0.8346 | 0.7809 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 0.267 | uM | 11851.155 | 0.8951 | 0.8627 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 1.33 | uM | 11851.155 | 0.2480 | -0.1826 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 6.67 | uM | 11851.155 | 0.6153 | 0.4645 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 33.3 | uM | 11851.155 | 0.7015 | 0.5930 | 1.5585 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10875.155 | 1.0122 | 1.0331 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10875.155 | 1.0966 | 1.2647 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10875.155 | 0.9984 | 0.9957 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10875.155 | 1.0828 | 1.2263 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10875.155 | 0.9425 | 0.8465 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.267 | uM | 10875.155 | 0.9080 | 0.7561 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 1.33 | uM | 10875.155 | 0.4668 | -0.2835 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 6.67 | uM | 10875.155 | 0.6109 | 0.0295 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 33.3 | uM | 10875.155 | 0.8560 | 0.6219 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12428.155 | 1.0134 | 1.0350 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12428.155 | 0.9991 | 0.9978 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12428.155 | 1.0136 | 1.0357 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12428.155 | 0.9581 | 0.8912 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12428.155 | 1.0234 | 1.0613 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.267 | uM | 12428.155 | 0.7020 | 0.2598 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 1.33 | uM | 12428.155 | 0.4704 | -0.2534 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 6.67 | uM | 12428.155 | 0.5398 | -0.1063 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 33.3 | uM | 12428.155 | 0.6051 | 0.0374 | 0.7654 | |
| SUM149PT | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10819.155 | 1.0954 | 1.0907 | 2.0561 | |
| SUM149PT | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10819.155 | 1.0111 | 1.0107 | 2.0561 |