Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 17.1 | uM | 9347.121 | 0.7983 | 0.7127 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 85.2 | uM | 9347.121 | 0.1623 | -0.4281 | 1.4523 | |
| HCC1806 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9376.121 | 1.0260 | 1.0376 | 1.3803 | |
| HCC1806 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9376.121 | 1.1143 | 1.1632 | 1.3803 | |
| HCC1806 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9376.121 | 1.0794 | 1.1138 | 1.3803 | |
| HCC1806 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9376.121 | 1.0791 | 1.1134 | 1.3803 | |
| HCC1806 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.136 | uM | 9376.121 | 1.0205 | 1.0296 | 1.3803 | |
| HCC1806 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.682 | uM | 9376.121 | 0.7519 | 0.6268 | 1.3803 | |
| HCC1806 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 3.41 | uM | 9376.121 | 0.5255 | 0.2549 | 1.3803 | |
| HCC1806 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 17.1 | uM | 9376.121 | 0.2564 | -0.2538 | 1.3803 | |
| HCC1806 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 85.2 | uM | 9376.121 | 0.0330 | -0.8311 | 1.3803 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7833.007 | 1.0139 | 1.0214 | 1.2952 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7833.007 | 0.9856 | 0.9777 | 1.2952 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7833.007 | 1.1265 | 1.1926 | 1.2952 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7833.007 | 0.9734 | 0.9588 | 1.2952 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.118 | uM | 7833.007 | 1.0204 | 1.0314 | 1.2952 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.59 | uM | 7833.007 | 0.9427 | 0.9109 | 1.2952 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 2.95 | uM | 7833.007 | 0.8405 | 0.7488 | 1.2952 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 14.8 | uM | 7833.007 | 0.6430 | 0.4222 | 1.2952 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 73.8 | uM | 7833.007 | 0.3803 | -0.0519 | 1.2952 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000189 | uM | 10262.034 | 1.0010 | 1.0030 | 0.6634 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000945 | uM | 10262.034 | 0.9959 | 0.9878 | 0.6634 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.00472 | uM | 10262.034 | 1.0030 | 1.0091 | 0.6634 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.0236 | uM | 10262.034 | 0.9800 | 0.9401 | 0.6634 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.118 | uM | 10262.034 | 0.9751 | 0.9253 | 0.6634 |