Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.59 | uM | 10262.034 | 0.9504 | 0.8523 | 0.6634 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 2.95 | uM | 10262.034 | 0.8787 | 0.6457 | 0.6634 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 14.8 | uM | 10262.034 | 0.7034 | 0.1767 | 0.6634 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 73.8 | uM | 10262.034 | 0.1747 | -0.8558 | 0.6634 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7837.007 | 0.9878 | 0.9851 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7837.007 | 1.0322 | 1.0390 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7837.007 | 0.9343 | 0.9190 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7837.007 | 1.1422 | 1.1685 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.118 | uM | 7837.007 | 1.0433 | 1.0523 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.59 | uM | 7837.007 | 1.0327 | 1.0396 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 2.95 | uM | 7837.007 | 1.0012 | 1.0015 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 14.8 | uM | 7837.007 | 0.7526 | 0.6824 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 73.8 | uM | 7837.007 | 0.0490 | -0.6809 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9386.121 | 1.0525 | 1.0892 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9386.121 | 1.1044 | 1.1767 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9386.121 | 0.9813 | 0.9680 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9386.121 | 1.0276 | 1.0470 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.136 | uM | 9386.121 | 1.0079 | 1.0135 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 0.682 | uM | 9386.121 | 0.9613 | 0.9338 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 3.41 | uM | 9386.121 | 0.9195 | 0.8618 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 17.1 | uM | 9386.121 | 0.7864 | 0.6295 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 85.2 | uM | 9386.121 | 0.0760 | -0.7778 | 1.1728 | |
| HCC202 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 7841.077 | 1.0235 | 1.1065 | 0.4474 | |
| HCC202 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 7841.077 | 0.9126 | 0.6302 | 0.4474 | |
| HCC202 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 7841.077 | 0.9044 | 0.5978 | 0.4474 |