Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9095.121 | 0.9986 | 0.9976 | 1.1992 | |
| 184B5 | NM | Basal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9095.121 | 1.0077 | 1.0128 | 1.1992 | |
| 184B5 | NM | Basal | CPT-11 | TOP1 | TOP | 0.136 | uM | 9095.121 | 0.9403 | 0.9000 | 1.1992 | |
| 184B5 | NM | Basal | CPT-11 | TOP1 | TOP | 0.682 | uM | 9095.121 | 0.7275 | 0.5340 | 1.1992 | |
| 184B5 | NM | Basal | CPT-11 | TOP1 | TOP | 3.41 | uM | 9095.121 | 0.6390 | 0.3766 | 1.1992 | |
| 184B5 | NM | Basal | CPT-11 | TOP1 | TOP | 17.1 | uM | 9095.121 | 0.5815 | 0.2725 | 1.1992 | |
| 184B5 | NM | Basal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9095.121 | 0.3014 | -0.2643 | 1.1992 | |
| 600MPE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 9120.034 | 1.0431 | 1.1460 | 0.5982 | |
| 600MPE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 9120.034 | 1.0550 | 1.1873 | 0.5982 | |
| 600MPE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 9120.034 | 1.0534 | 1.1818 | 0.5982 | |
| 600MPE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 9120.034 | 1.0700 | 1.2395 | 0.5982 | |
| 600MPE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 9120.034 | 1.0473 | 1.1607 | 0.5982 | |
| 600MPE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 9120.034 | 1.0237 | 1.0797 | 0.5982 | |
| 600MPE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 9120.034 | 0.9955 | 0.9848 | 0.5982 | |
| 600MPE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 9120.034 | 0.9212 | 0.7435 | 0.5982 | |
| 600MPE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 9120.034 | 0.6290 | -0.0787 | 0.5982 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7793.007 | 1.0149 | 1.0215 | 1.3832 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7793.007 | 0.9210 | 0.8844 | 1.3832 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7793.007 | 0.9620 | 0.9448 | 1.3832 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7793.007 | 1.0376 | 1.0541 | 1.3832 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 7793.007 | 0.9937 | 0.9909 | 1.3832 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 7793.007 | 0.7894 | 0.6857 | 1.3832 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 7793.007 | 0.3396 | -0.0839 | 1.3832 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 7793.007 | 0.1235 | -0.5592 | 1.3832 | |
| AU565 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 7793.007 | 0.0816 | -0.6733 | 1.3832 |