Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 9386.017 | 0.1252 | -0.5629 | 1.3666 | |
| HCC1954 | HER2amp | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 9386.017 | 0.0157 | -0.9042 | 1.3666 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7846.017 | 1.1490 | 2.0084 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7846.017 | 1.0325 | 1.1969 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7846.017 | 1.0199 | 1.1195 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 7846.017 | 0.9626 | 0.7880 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 7846.017 | 1.0889 | 1.5689 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 7846.017 | 0.9361 | 0.6474 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 7846.017 | 0.3863 | -0.8778 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 7846.017 | 0.0810 | -0.9988 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 7846.017 | 0.0212 | -1.0000 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7848.017 | 1.0699 | 1.4658 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7848.017 | 1.0206 | 1.1305 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7848.017 | 1.0557 | 1.3659 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 7848.017 | 1.0181 | 1.1145 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 7848.017 | 1.0794 | 1.5343 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 7848.017 | 0.9348 | 0.6224 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 7848.017 | 0.6484 | -0.4780 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 7848.017 | 0.2546 | -0.9712 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 7848.017 | 0.0076 | -1.0000 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7849.017 | 0.9949 | 0.9709 | 0.3471 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7849.017 | 0.9964 | 0.9792 | 0.3471 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7849.017 | 1.0894 | 1.5597 | 0.3471 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 7849.017 | 1.0179 | 1.1051 | 0.3471 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 7849.017 | 1.0282 | 1.1669 | 0.3471 |