Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12959.177 | 0.0113 | -0.9994 | 0.5538 | |
| MDA-MB-415 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12959.177 | 0.0078 | -0.9997 | 0.5538 | |
| MDA-MB-453 | TNBC | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12964.177 | 0.9226 | 0.7962 | 0.7495 | |
| MDA-MB-453 | TNBC | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12964.177 | 0.9233 | 0.7979 | 0.7495 | |
| MDA-MB-453 | TNBC | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12964.177 | 0.9604 | 0.8949 | 0.7495 | |
| MDA-MB-453 | TNBC | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12964.177 | 1.0563 | 1.1516 | 0.7495 | |
| MDA-MB-453 | TNBC | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12964.177 | 0.7979 | 0.4799 | 0.7495 | |
| MDA-MB-453 | TNBC | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12964.177 | 0.5242 | -0.1551 | 0.7495 | |
| MDA-MB-453 | TNBC | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12964.177 | 0.0047 | -0.9984 | 0.7495 | |
| MDA-MB-453 | TNBC | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12964.177 | 0.0098 | -0.9959 | 0.7495 | |
| MDA-MB-453 | TNBC | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12964.177 | 0.0031 | -0.9991 | 0.7495 | |
| MX1 | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12667.177 | 1.0535 | 1.1851 | 0.5892 | |
| MX1 | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12667.177 | 0.9939 | 0.9795 | 0.5892 | |
| MX1 | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12667.177 | 1.0412 | 1.1417 | 0.5892 | |
| MX1 | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12667.177 | 1.0404 | 1.1389 | 0.5892 | |
| MX1 | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12667.177 | 0.0180 | -0.9978 | 0.5892 | |
| MX1 | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12667.177 | 0.0163 | -0.9982 | 0.5892 | |
| MX1 | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12667.177 | 0.0037 | -0.9999 | 0.5892 | |
| MX1 | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12667.177 | 0.0107 | -0.9991 | 0.5892 | |
| MX1 | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12667.177 | 0.0002 | -1.0000 | 0.5892 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 13009.177 | 0.9988 | 0.9980 | 1.2366 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 13009.177 | 0.9760 | 0.9611 | 1.2366 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 13009.177 | 1.0700 | 1.1125 | 1.2366 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 13009.177 | 1.0955 | 1.1530 | 1.2366 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 13009.177 | 0.0725 | -0.7605 | 1.2366 |