Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12632.177 | 0.9909 | 0.9730 | 0.6753 | |
| MDA-MB-157 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12632.177 | 1.0108 | 1.0322 | 0.6753 | |
| MDA-MB-157 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12632.177 | 1.0133 | 1.0395 | 0.6753 | |
| MDA-MB-157 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12632.177 | 1.0590 | 1.1772 | 0.6753 | |
| MDA-MB-157 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12632.177 | 0.7696 | 0.3571 | 0.6753 | |
| MDA-MB-157 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12632.177 | 0.0090 | -0.9981 | 0.6753 | |
| MDA-MB-157 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12632.177 | 0.0065 | -0.9988 | 0.6753 | |
| MDA-MB-157 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12632.177 | 0.0077 | -0.9985 | 0.6753 | |
| MDA-MB-157 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12632.177 | 0.0012 | -0.9999 | 0.6753 | |
| MDA-MB-361 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12989.177 | 1.0185 | 1.0998 | 0.3765 | |
| MDA-MB-361 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12989.177 | 0.9204 | 0.6046 | 0.3765 | |
| MDA-MB-361 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12989.177 | 1.0562 | 1.3124 | 0.3765 | |
| MDA-MB-361 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12989.177 | 1.0411 | 1.2259 | 0.3765 | |
| MDA-MB-361 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12989.177 | 0.9797 | 0.8940 | 0.3765 | |
| MDA-MB-361 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12989.177 | 0.8180 | 0.1731 | 0.3765 | |
| MDA-MB-361 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12989.177 | 0.0017 | -1.0000 | 0.3765 | |
| MDA-MB-361 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12989.177 | 0.0034 | -1.0000 | 0.3765 | |
| MDA-MB-361 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12989.177 | 0.0004 | -1.0000 | 0.3765 | |
| MDA-MB-415 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12959.177 | 0.9641 | 0.8721 | 0.5538 | |
| MDA-MB-415 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12959.177 | 1.0116 | 1.0422 | 0.5538 | |
| MDA-MB-415 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12959.177 | 1.0548 | 1.2022 | 0.5538 | |
| MDA-MB-415 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12959.177 | 1.0009 | 1.0033 | 0.5538 | |
| MDA-MB-415 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12959.177 | 0.7957 | 0.3238 | 0.5538 | |
| MDA-MB-415 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12959.177 | 0.0125 | -0.9993 | 0.5538 | |
| MDA-MB-415 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12959.177 | 0.0077 | -0.9997 | 0.5538 |