Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 13009.177 | 0.0134 | -0.9389 | 1.2366 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 13009.177 | 0.0075 | -0.9619 | 1.2366 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 13009.177 | 0.0128 | -0.9411 | 1.2366 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 13009.177 | 0.0055 | -0.9703 | 1.2366 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 13062.177 | 0.9934 | 0.9926 | 1.7820 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 13062.177 | 0.9763 | 0.9733 | 1.7820 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 13062.177 | 1.0197 | 1.0220 | 1.7820 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 13062.177 | 1.0075 | 1.0084 | 1.7820 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 13062.177 | 0.1699 | -0.2604 | 1.7820 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 13062.177 | 0.0144 | -0.8151 | 1.7820 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 13062.177 | 0.0081 | -0.8662 | 1.7820 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 13062.177 | 0.0122 | -0.8314 | 1.7820 | |
| SUM229PE | TNBC | - | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 13062.177 | 0.0064 | -0.8823 | 1.7820 | |
| T47DKBLUC | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 13070.177 | 0.9412 | 0.8704 | 0.9040 | |
| T47DKBLUC | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 13070.177 | 0.9806 | 0.9571 | 0.9040 | |
| T47DKBLUC | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 13070.177 | 0.9682 | 0.9297 | 0.9040 | |
| T47DKBLUC | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 13070.177 | 0.9114 | 0.8049 | 0.9040 | |
| T47DKBLUC | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 13070.177 | 0.8926 | 0.7638 | 0.9040 | |
| T47DKBLUC | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 13070.177 | 0.0131 | -0.9834 | 0.9040 | |
| T47DKBLUC | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 13070.177 | 0.0089 | -0.9892 | 0.9040 | |
| T47DKBLUC | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 13070.177 | 0.0124 | -0.9845 | 0.9040 | |
| T47DKBLUC | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 13070.177 | 0.0001 | -0.9999 | 0.9040 | |
| ZR-75-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0000854 | uM | 12677.177 | 0.9570 | 0.9181 | 1.0515 | |
| ZR-75-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.000427 | uM | 12677.177 | 0.9727 | 0.9481 | 1.0515 | |
| ZR-75-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.00213 | uM | 12677.177 | 0.9782 | 0.9586 | 1.0515 |