Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0107 | uM | 12677.177 | 0.9967 | 0.9937 | 1.0515 | |
| ZR-75-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.0534 | uM | 12677.177 | 0.9655 | 0.9344 | 1.0515 | |
| ZR-75-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 0.267 | uM | 12677.177 | 0.0998 | -0.7766 | 1.0515 | |
| ZR-75-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 1.33 | uM | 12677.177 | 0.0098 | -0.9755 | 1.0515 | |
| ZR-75-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 6.67 | uM | 12677.177 | 0.0132 | -0.9673 | 1.0515 | |
| ZR-75-1 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 33.3 | uM | 12677.177 | 0.0066 | -0.9831 | 1.0515 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 9047.011 | 0.8651 | 0.5888 | 0.6293 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 9047.011 | 1.0132 | 1.0422 | 0.6293 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 9047.011 | 0.8944 | 0.6751 | 0.6293 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 9047.011 | 0.9713 | 0.9094 | 0.6293 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.15 | uM | 9047.011 | 0.9736 | 0.9167 | 0.6293 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 9047.011 | 0.7942 | 0.3868 | 0.6293 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 9047.011 | 0.2011 | -0.8437 | 0.6293 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 9047.011 | 0.2555 | -0.7713 | 0.6293 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 9047.011 | 0.0414 | -0.9873 | 0.6293 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 10002.021 | 0.9479 | 0.8567 | 0.7195 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0172 | uM | 10002.021 | 0.9823 | 0.9511 | 0.7195 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.0862 | uM | 10002.021 | 0.9682 | 0.9121 | 0.7195 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.431 | uM | 10002.021 | 0.9719 | 0.9224 | 0.7195 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 2.16 | uM | 10002.021 | 1.0013 | 1.0037 | 0.7195 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 10.8 | uM | 10002.021 | 0.8933 | 0.7096 | 0.7195 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 53.9 | uM | 10002.021 | 0.2557 | -0.6995 | 0.7195 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 269 | uM | 10002.021 | 0.2340 | -0.7344 | 0.7195 | |
| 184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 1350 | uM | 10002.021 | 0.1715 | -0.8276 | 0.7195 | |
| 184B5 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 0.00345 | uM | 9095.119 | 1.0723 | 1.1172 | 1.2263 |