Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 10754.145 | 0.8745 | 0.7585 | 1.0421 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 4 | uM | 10754.145 | 0.5376 | 0.1024 | 1.0421 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 20 | uM | 10754.145 | 0.3478 | -0.2742 | 1.0421 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 100 | uM | 10754.145 | 0.2908 | -0.3887 | 1.0421 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 11938.145 | 0.8603 | 0.6162 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 11938.145 | 0.8742 | 0.6532 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 11938.145 | 0.9163 | 0.7672 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 11938.145 | 0.8946 | 0.7081 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 11938.145 | 0.9313 | 0.8084 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 11938.145 | 0.9228 | 0.7849 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 4 | uM | 11938.145 | 0.7645 | 0.3674 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 20 | uM | 11938.145 | 0.5956 | -0.0398 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 100 | uM | 11938.145 | 0.3996 | -0.4542 | 0.7062 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 11660.145 | 0.9550 | 0.9021 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 11660.145 | 0.9707 | 0.9361 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 11660.145 | 0.9644 | 0.9225 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 11660.145 | 0.9863 | 0.9702 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 11660.145 | 1.0060 | 1.0130 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 11660.145 | 0.9411 | 0.8718 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 4 | uM | 11660.145 | 0.8544 | 0.6845 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 20 | uM | 11660.145 | 0.1722 | -0.7064 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 100 | uM | 11660.145 | 0.0121 | -0.9838 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 12003.145 | 1.0156 | 1.0325 | 0.9611 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 12003.145 | 0.9648 | 0.9268 | 0.9611 | |
| ZR-75-1 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 12003.145 | 0.9942 | 0.9880 | 0.9611 |