Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | Bosutinib | Src | nRTK | 20 | uM | 10939.145 | 0.0398 | -0.7146 | 1.6558 | |
| T47D | HR+ | Luminal | Bosutinib | Src | nRTK | 100 | uM | 10939.145 | 0.4109 | 0.1688 | 1.6558 | |
| T47DKBLUC | Unknown | Unknown | Bosutinib | Src | nRTK | 0.0000853 | uM | 12608.17 | 0.9465 | 0.9006 | 1.0776 | |
| T47DKBLUC | Unknown | Unknown | Bosutinib | Src | nRTK | 0.000427 | uM | 12608.17 | 0.9526 | 0.9120 | 1.0776 | |
| T47DKBLUC | Unknown | Unknown | Bosutinib | Src | nRTK | 0.00213 | uM | 12608.17 | 0.9624 | 0.9301 | 1.0776 | |
| T47DKBLUC | Unknown | Unknown | Bosutinib | Src | nRTK | 0.0107 | uM | 12608.17 | 0.9741 | 0.9519 | 1.0776 | |
| T47DKBLUC | Unknown | Unknown | Bosutinib | Src | nRTK | 0.0533 | uM | 12608.17 | 0.9640 | 0.9331 | 1.0776 | |
| T47DKBLUC | Unknown | Unknown | Bosutinib | Src | nRTK | 0.267 | uM | 12608.17 | 0.9685 | 0.9415 | 1.0776 | |
| T47DKBLUC | Unknown | Unknown | Bosutinib | Src | nRTK | 1.33 | uM | 12608.17 | 1.0159 | 1.0295 | 1.0776 | |
| T47DKBLUC | Unknown | Unknown | Bosutinib | Src | nRTK | 6.67 | uM | 12608.17 | 0.8109 | 0.6465 | 1.0776 | |
| T47DKBLUC | Unknown | Unknown | Bosutinib | Src | nRTK | 33.3 | uM | 12608.17 | 0.7944 | 0.6154 | 1.0776 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 10580.145 | 0.9080 | 0.7966 | 0.9000 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 10580.145 | 0.9126 | 0.8067 | 0.9000 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 10580.145 | 0.9154 | 0.8128 | 0.9000 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 10580.145 | 0.9540 | 0.8981 | 0.9000 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 10580.145 | 1.0101 | 1.0224 | 0.9000 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 10580.145 | 0.9101 | 0.8012 | 0.9000 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 4 | uM | 10580.145 | 0.7133 | 0.3741 | 0.9000 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 20 | uM | 10580.145 | 0.5656 | 0.0618 | 0.9000 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 100 | uM | 10580.145 | 0.4008 | -0.2758 | 0.9000 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 10754.145 | 0.9141 | 0.8348 | 1.0421 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 10754.145 | 0.9409 | 0.8865 | 1.0421 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 10754.145 | 0.9990 | 0.9980 | 1.0421 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 10754.145 | 1.0527 | 1.1011 | 1.0421 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 10754.145 | 1.1033 | 1.1980 | 1.0421 |