Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 10997.145 | 0.9012 | 0.8562 | 1.3945 | |
| MCF7 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 10997.145 | 1.0258 | 1.0369 | 1.3945 | |
| MCF7 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 10997.145 | 0.9555 | 0.9357 | 1.3945 | |
| MCF7 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 10997.145 | 0.9385 | 0.9111 | 1.3945 | |
| MCF7 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 10997.145 | 0.9202 | 0.8843 | 1.3945 | |
| MCF7 | HR+ | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 10997.145 | 0.8028 | 0.7086 | 1.3945 | |
| MCF7 | HR+ | Luminal | Bosutinib | Src | nRTK | 4 | uM | 10997.145 | 0.6513 | 0.4705 | 1.3945 | |
| MCF7 | HR+ | Luminal | Bosutinib | Src | nRTK | 20 | uM | 10997.145 | 0.4840 | 0.1886 | 1.3945 | |
| MCF7 | HR+ | Luminal | Bosutinib | Src | nRTK | 100 | uM | 10997.145 | 0.5314 | 0.2709 | 1.3945 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 10998.145 | 0.8727 | 0.7304 | 0.9403 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 10998.145 | 0.8798 | 0.7454 | 0.9403 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 10998.145 | 0.8907 | 0.7683 | 0.9403 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 10998.145 | 0.8608 | 0.7054 | 0.9403 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 10998.145 | 0.9342 | 0.8604 | 0.9403 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 10998.145 | 0.8938 | 0.7748 | 0.9403 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 4 | uM | 10998.145 | 0.9556 | 0.9056 | 0.9403 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 20 | uM | 10998.145 | 0.8771 | 0.7397 | 0.9403 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 100 | uM | 10998.145 | 0.8967 | 0.7810 | 0.9403 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 0.000256 | uM | 12206.145 | 0.9660 | 0.9222 | 0.8709 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 0.00128 | uM | 12206.145 | 0.9691 | 0.9293 | 0.8709 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 0.0064 | uM | 12206.145 | 1.0207 | 1.0475 | 0.8709 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 0.032 | uM | 12206.145 | 0.9902 | 0.9775 | 0.8709 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 0.16 | uM | 12206.145 | 1.0138 | 1.0318 | 0.8709 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 0.8 | uM | 12206.145 | 1.0199 | 1.0458 | 0.8709 | |
| MDA-MB-134-VI | HR+ | Luminal | Bosutinib | Src | nRTK | 4 | uM | 12206.145 | 1.0341 | 1.0785 | 0.8709 |